AFfirm™ ACTN3 Mouse Monoclonal Antibody - #BF8653
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ/展開
Actinin alpha 3; actinin, alpha; ACTN 3; ACTN3; ACTN3_HUMAN; Alpha actinin skeletal muscle; Alpha actinin skeletal muscle isoform 3; Alpha-Actinin 3; Alpha-actinin skeletal muscle isoform 3; Alpha-actinin-3; F actin cross linking protein; F-actin cross-linking protein; MGC117002; MGC117005; OTTHUMP00000219049; OTTHUMP00000219054;
免疫原
A synthesized peptide derived from human ACTN3, corresponding to a region within C-terminal amino acids.
- Q08043 ACTN3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MMMVMQPEGLGAGEGRFAGGGGGGEYMEQEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPRPDKGKMRFHKIANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDLIDYAKLRKDDPIGNLNTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAANRICKVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRRLHKPPRIQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDRLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSCDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAKVEEVGRLAAGLAGSLEEQMAGLRQQEQNIINYKTNIDRLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLLTSIARTINEVENQVLTRDAKGLSQEQLNEFRASFNHFDRKQNGMMEPDDFRACLISMGYDLGEVEFARIMTMVDPNAAGVVTFQAFIDFMTRETAETDTTEQVVASFKILAGDKNYITPEELRRELPAKQAEYCIRRMVPYKGSGAPAGALDYVAFSSALYGESDL
PTMs - Q08043 基板として
Site | PTM Type | Enzyme | Source |
---|---|---|---|
M1 | Acetylation | Uniprot | |
K45 | Ubiquitination | Uniprot | |
K49 | Ubiquitination | Uniprot | |
K61 | Ubiquitination | Uniprot | |
T64 | Phosphorylation | Uniprot | |
R90 | Methylation | Uniprot | |
R93 | Methylation | Uniprot | |
S116 | Phosphorylation | Uniprot | |
K117 | Ubiquitination | Uniprot | |
T137 | Phosphorylation | Uniprot | |
S154 | Phosphorylation | Uniprot | |
T158 | Phosphorylation | Uniprot | |
S159 | Phosphorylation | Uniprot | |
K209 | Sumoylation | Uniprot | |
K212 | Sumoylation | Uniprot | |
Y229 | Phosphorylation | Uniprot | |
K250 | Acetylation | Uniprot | |
S257 | Phosphorylation | Uniprot | |
Y260 | Phosphorylation | Uniprot | |
R275 | Methylation | Uniprot | |
K278 | Acetylation | Uniprot | |
S298 | Phosphorylation | Uniprot | |
S319 | Phosphorylation | Uniprot | |
S321 | Phosphorylation | Uniprot | |
Y333 | Phosphorylation | Uniprot | |
T354 | Phosphorylation | Uniprot | |
T357 | Phosphorylation | Uniprot | |
S376 | Phosphorylation | Uniprot | |
S418 | Phosphorylation | Uniprot | |
Y436 | Phosphorylation | Uniprot | |
S438 | Phosphorylation | Uniprot | |
S456 | Phosphorylation | Uniprot | |
K506 | Acetylation | Uniprot | |
S737 | Phosphorylation | Uniprot | |
Y851 | Phosphorylation | Uniprot | |
Y876 | Phosphorylation | Uniprot |
研究背景
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
Expressed only in a subset of type 2 skeletal muscle fibers.
Homodimer; antiparallel. Also forms heterodimers with ACTN2. Interacts with MYOZ1.
Belongs to the alpha-actinin family.
研究領域
· Human Diseases > Cardiovascular diseases > Arrhythmogenic right ventricular cardiomyopathy (ARVC).
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