AFfirm™ UGT2B15 Mouse Monoclonal Antibody - #BF8677
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
EC 2.4.1.17; HLUG4; UDB15_HUMAN; UDP glucuronosyltransferase 2 family polypeptide B15; UDP glucuronosyltransferase 2 family, member B15; UDP glucuronosyltransferase 2 family, member B8; UDP glucuronosyltransferase 2B15; UDP glucuronosyltransferase UGT2B15; UDP glucuronyltransferase family 2 beta 15; UDP glycosyltransferase 2 family, member B15; UDP glycosyltransferase 2B15; UDP-glucuronosyltransferase 2B15; UDP-glucuronosyltransferase 2B8; UDPGT 2B15; UDPGT 2B8; UDPGT2B15; UDPGTh 3; UDPGTh-3; UDPGTH3; UGT2B15; UGT2B8; Uridine diphosphate glucuronosyltransferase 2 family, member B8; Uridine diphosphate glycosyltransferase 2 family, member B15;
免疫原
A synthesized peptide derived from human UGT2B15.
- P54855 UDB15_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSLKWTSVFLLIQLSCYFSSGSCGKVLVWPTEYSHWINMKTILEELVQRGHEVTVLTSSASTLVNASKSSAIKLEVYPTSLTKNYLEDSLLKILDRWIYGVSKNTFWSYFSQLQELCWEYYDYSNKLCKDAVLNKKLMMKLQESKFDVILADALNPCGELLAELFNIPFLYSLRFSVGYTFEKNGGGFLFPPSYVPVVMSELSDQMIFMERIKNMIHMLYFDFWFQIYDLKKWDQFYSEVLGRPTTLFETMGKAEMWLIRTYWDFEFPRPFLPNVDFVGGLHCKPAKPLPKEMEEFVQSSGENGIVVFSLGSMISNMSEESANMIASALAQIPQKVLWRFDGKKPNTLGSNTRLYKWLPQNDLLGHPKTKAFITHGGTNGIYEAIYHGIPMVGIPLFADQHDNIAHMKAKGAALSVDIRTMSSRDLLNALKSVINDPVYKENVMKLSRIHHDQPMKPLDRAVFWIEFVMRHKGAKHLRVAAHNLTWIQYHSLDVIAFLLACVATVIFIITKFCLFCFRKLAKKGKKKKRD
研究背景
UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme displays activity toward several classes of xenobiotic substrates, including simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolites. It also catalyzes the glucuronidation of endogenous estrogens and androgens.
Microsome membrane>Single-pass membrane protein. Endoplasmic reticulum membrane>Single-pass membrane protein.
Expressed in many tissues. Present in liver, prostate and testis.
Belongs to the UDP-glycosyltransferase family.
研究領域
· Human Diseases > Cancers: Overview > Chemical carcinogenesis.
· Metabolism > Carbohydrate metabolism > Pentose and glucuronate interconversions.
· Metabolism > Carbohydrate metabolism > Ascorbate and aldarate metabolism.
· Metabolism > Lipid metabolism > Steroid hormone biosynthesis.
· Metabolism > Metabolism of cofactors and vitamins > Retinol metabolism.
· Metabolism > Metabolism of cofactors and vitamins > Porphyrin and chlorophyll metabolism.
· Metabolism > Xenobiotics biodegradation and metabolism > Metabolism of xenobiotics by cytochrome P450.
· Metabolism > Xenobiotics biodegradation and metabolism > Drug metabolism - cytochrome P450.
· Metabolism > Xenobiotics biodegradation and metabolism > Drug metabolism - other enzymes.
· Metabolism > Global and overview maps > Metabolic pathways.
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