AFfirm™ TBC1D21 Mouse Monoclonal Antibody - #BF8680

製品: TBC1D21 Mouse Monoclonal Antibody
カタログ: BF8680
タンパク質の説明: Mouse monoclonal antibody to TBC1D21
アプリケーション: WB
反応性: Human
予測: Human
分子量: 50kD; 39kD(Calculated).
ユニプロット: Q8IYX1

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MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Mouse
アプリケーション:
WB 1:500-1:3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human
クローナリティ:
Monoclonal [AFfirm8680]
特異性:
TBC1D21 Mouse Monoclonal Antibody detects endogenous levels of TBC1D21.
コンジュゲート:
Unconjugated.
精製:
Affinity-chromatography.
保存:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

male germ cell-specific expressed, containing a RabGAP domain; MGC34741; MgcRabGAP; OTTHUMP00000174928; TBC1 domain family member 21; TBC1D21; TBC21_HUMAN;

免疫原

免疫原:

A synthesized peptide derived from human TBC1D21.

Uniprot:

Q8IYX1(TBC21_HUMAN) >>Visit HPA database.

遺伝子(ID):
TBC1D21(161514)
発現特異性:
Q8IYX1 TBC21_HUMAN:

Expressed in round and elongated spermatids (at protein level). Expressed specifically in adult testis and very weakly in fetal brain.

タンパク質配列:
MTTLSPENSLSARQSASFILVKRKPPIDKTEWDSFFDESGHLAKSRDFICVNILERGLHPFVRTEAWKFLTGYFSWQSSQDERLTVDSMRRKNYKALCQMYEKIQPLLENLHRNFTETRNNIARDIQKIYDKDPLGNVLIDKKRLEKILLLSYVCNTQAEYQQGFHEMMMLFQLMVEHDHETFWLFQFFLQKTEHSCVINIGVAKNLDMLSTLITFLDPVFAEHLKGKGAGAVQSLFPWFCFCFQRAFKSFDDVWRLWEVLLTGKPCRNFQVLVAYSMLQMVREQVLQESMGGDDILLACNNLIDLDADELISAACVVYAELIQKDVPQTLKDFFL

研究背景

機能:

May act as a GTPase-activating protein for Rab family protein(s). May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity.

細胞の位置付け:

Cytoplasmic vesicle>Secretory vesicle>Acrosome. Cytoplasm>Cytoskeleton.
Note: Located at the edge of the acrosomal region, neck and annulus during spermiogenesis. Colocalizes with RAB3A at the acrosome-acroplaxome and neck regions of spermatids. Colocalizes with ACTB at the neck region in elongated spermatids.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Expressed in round and elongated spermatids (at protein level). Expressed specifically in adult testis and very weakly in fetal brain.

サブユニット構造:

Interacts with ACTB.

タンパク質ファミリー:

The arginine and glutamine fingers are critical for the GTPase-activating mechanism, they pull out Rab's 'switch 2' glutamine and insert in Rab's active site.

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