AFfirm™ GUCA1A Mouse Monoclonal Antibody - #BF8693

製品: GUCA1A Mouse Monoclonal Antibody
カタログ: BF8693
タンパク質の説明: Mouse monoclonal antibody to GUCA1A
アプリケーション: WB
反応性: Human
予測: Mouse
分子量: 23kD(Calculated).
ユニプロット: P43080

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MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Mouse
アプリケーション:
WB 1:500-1:3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human
クローナリティ:
Monoclonal [AFfirm8693]
特異性:
GUCA1A Mouse Monoclonal Antibody detects endogenous levels of GUCA1A.
コンジュゲート:
Unconjugated.
精製:
Affinity-chromatography.
保存:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

COD3; GCAP 1; GCAP; Guanylate Cyclase Activating Protein Photoreceptor 1; Guanylate cyclase activator 1A; Guanylin 1; guanylyl cyclase activating protein 1; Guanylyl cyclase-activating protein 1; GUC1A_HUMAN; GUCA; GUCA1; GUCA1A;

免疫原

免疫原:

A synthesized peptide derived from human GUCA1A.

Uniprot:

P43080(GUC1A_HUMAN) >>Visit HPA database.

遺伝子(ID):
GUCA1A(2978)
発現特異性:
P43080 GUC1A_HUMAN:

Retina; cone outer and inner segments, in particular, in disk membrane regions, and to a lesser extent rod inner and outer segments.

タンパク質配列:
MGNVMEGKSVEELSSTECHQWYKKFMTECPSGQLTLYEFRQFFGLKNLSPSASQYVEQMFETFDFNKDGYIDFMEYVAALSLVLKGKVEQKLRWYFKLYDVDGNGCIDRDELLTIIQAIRAINPCSDTTMTAEEFTDTVFSKIDVNGDGELSLEEFIEGVQKDQMLLDTLTRSLDLTRIVRRLQNGEQDEEGADEAAEAAG

研究背景

機能:

Stimulates retinal guanylyl cyclase when free calcium ions concentration is low and inhibits guanylyl cyclase when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of retinal guanylyl cyclase is a key event in recovery of the dark state of rod photoreceptors following light exposure (By similarity). May be involved in cone photoreceptor light response and recovery of response in bright light (By similarity).

細胞の位置付け:

Membrane>Lipid-anchor. Cell projection>Cilium>Photoreceptor outer segment.
Note: Subcellular location is not affected by light or dark conditions.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Retina; cone outer and inner segments, in particular, in disk membrane regions, and to a lesser extent rod inner and outer segments.

タンパク質ファミリー:

Binds three calcium ions (via EF-hands 2, 3 and 4) when calcium levels are high. Binds Mg(2+) when calcium levels are low.

研究領域

· Organismal Systems > Sensory system > Phototransduction.

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