AFfirm™ PMPCA Mouse Monoclonal Antibody - #BF8725

製品: PMPCA Mouse Monoclonal Antibody
カタログ: BF8725
タンパク質の説明: Mouse monoclonal antibody to PMPCA
アプリケーション: WB
反応性: Human
予測: Mouse, Rat
分子量: 50kD; 58kD(Calculated).
ユニプロット: Q10713

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関連ダウンロード
MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Mouse
アプリケーション:
WB 1:500-1:3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human
クローナリティ:
Monoclonal [AFfirm8725]
特異性:
PMPCA Mouse Monoclonal Antibody detects endogenous levels of PMPCA.
コンジュゲート:
Unconjugated.
精製:
Affinity-chromatography.
保存:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

1200002L24Rik; 4933435E07Rik; Alpha MPP; Alpha-MPP; FLJ26258; Inositol polyphosphate 5 phosphatase, 72 kD; INPP5E; KIAA0123; MGC104197; MGC93916; Mitochondrial matrix processing protease, alpha subunit; mitochondrial processing peptidase subunit alpha; Mitochondrial-processing peptidase subunit alpha; MPPA_HUMAN; P 55; P-55; Peptidase (mitochondrial processing) alpha; pmpca; RP11-413M3.1; RP23-306D20.8; SCAR2;

免疫原

免疫原:

A synthesized peptide derived from human PMPCA.

Uniprot:

Q10713(MPPA_HUMAN) >>Visit HPA database.

遺伝子(ID):
PMPCA(23203)
発現特異性:
Q10713 MPPA_HUMAN:

Ubiquitously expressed with highest expression in fetal tissues and adult brain, cerebellum and cerebellar vermis.

タンパク質配列:
MAAVVLAATRLLRGSGSWGCSRLRFGPPAYRRFSSGGAYPNIPLSSPLPGVPKPVFATVDGQEKFETKVTTLDNGLRVASQNKFGQFCTVGILINSGSRYEAKYLSGIAHFLEKLAFSSTARFDSKDEILLTLEKHGGICDCQTSRDTTMYAVSADSKGLDTVVALLADVVLQPRLTDEEVEMTRMAVQFELEDLNLRPDPEPLLTEMIHEAAYRENTVGLHRFCPTENVAKINREVLHSYLRNYYTPDRMVLAGVGVEHEHLVDCARKYLLGVQPAWGSAEAVDIDRSVAQYTGGIAKLERDMSNVSLGPTPIPELTHIMVGLESCSFLEEDFIPFAVLNMMMGGGGSFSAGGPGKGMFSRLYLNVLNRHHWMYNATSYHHSYEDTGLLCIHASADPRQVREMVEIITKEFILMGGTVDTVELERAKTQLTSMLMMNLESRPVIFEDVGRQVLATRSRKLPHELCTLIRNVKPEDVKRVASKMLRGKPAVAALGDLTDLPTYEHIQTALSSKDGRLPRTYRLFR

研究背景

機能:

Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.

細胞の位置付け:

Mitochondrion matrix. Mitochondrion inner membrane.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Ubiquitously expressed with highest expression in fetal tissues and adult brain, cerebellum and cerebellar vermis.

サブユニット構造:

Heterodimer of PMPCA (alpha) and PMPCB (beta) subunits, forming the mitochondrial processing protease (MPP) in which PMPCA is involved in substrate recognition and binding and PMPCB is the catalytic subunit.

タンパク質ファミリー:

Belongs to the peptidase M16 family.

Restrictive clause

 

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