AFfirm™ COLGALT1 Mouse Monoclonal Antibody - #BF8774

製品: COLGALT1 Mouse Monoclonal Antibody
カタログ: BF8774
タンパク質の説明: Mouse monoclonal antibody to COLGALT1
アプリケーション: WB
反応性: Human
予測: Mouse
分子量: 72kD(Calculated).
ユニプロット: Q8NBJ5

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MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Mouse
アプリケーション:
WB 1:500-1:3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human
クローナリティ:
Monoclonal [AFfirm8774]
特異性:
COLGALT1 Mouse Monoclonal Antibody detects endogenous levels of COLGALT1.
コンジュゲート:
Unconjugated.
精製:
Affinity-chromatography.
保存:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

FLJ22329; Glycosyltransferase 25 domain containing 1; Hydroxylysine galactosyltransferase 1; Procollagen galactosyltransferase 1;

免疫原

免疫原:

A synthesized peptide derived from human COLGALT1.

Uniprot:

Q8NBJ5(GT251_HUMAN) >>Visit HPA database.

遺伝子(ID):
COLGALT1(79709)
発現特異性:
Q8NBJ5 GT251_HUMAN:

Ubiquitous with higher levels in placenta, heart, lung and spleen.

タンパク質配列:
MAAAPRAGRRRGQPLLALLLLLLAPLPPGAPPGADAYFPEERWSPESPLQAPRVLIALLARNAAHALPTTLGALERLRHPRERTALWVATDHNMDNTSTVLREWLVAVKSLYHSVEWRPAEEPRSYPDEEGPKHWSDSRYEHVMKLRQAALKSARDMWADYILFVDADNLILNPDTLSLLIAENKTVVAPMLDSRAAYSNFWCGMTSQGYYKRTPAYIPIRKRDRRGCFAVPMVHSTFLIDLRKAASRNLAFYPPHPDYTWSFDDIIVFAFSCKQAEVQMYVCNKEEYGFLPVPLRAHSTLQDEAESFMHVQLEVMVKHPPAEPSRFISAPTKTPDKMGFDEVFMINLRRRQDRRERMLRALQAQEIECRLVEAVDGKAMNTSQVEALGIQMLPGYRDPYHGRPLTKGELGCFLSHYNIWKEVVDRGLQKSLVFEDDLRFEIFFKRRLMNLMRDVEREGLDWDLIYVGRKRMQVEHPEKAVPRVRNLVEADYSYWTLAYVISLQGARKLLAAEPLSKMLPVDEFLPVMFDKHPVSEYKAHFSLRNLHAFSVEPLLIYPTHYTGDDGYVSDTETSVVWNNEHVKTDWDRAKSQKMREQQALSREAKNSDVLQSPLDSAARDEL

研究背景

機能:

Beta-galactosyltransferase that transfers beta-galactose to hydroxylysine residues of type I collagen. By acting on collagen glycosylation, facilitates the formation of collagen triple helix. Also involved in the biosynthesis of collagen type IV.

PTMs:

N-glycosylated.

細胞の位置付け:

Endoplasmic reticulum lumen.
Note: Colocalized with PLOD3 and mannose binding lectin/MBL2.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Ubiquitous with higher levels in placenta, heart, lung and spleen.

タンパク質ファミリー:

Belongs to the glycosyltransferase 25 family.

研究領域

· Metabolism > Amino acid metabolism > Lysine degradation.

· Metabolism > Glycan biosynthesis and metabolism > Other types of O-glycan biosynthesis.

Restrictive clause

 

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