AFfirm™ CYP26B1 Mouse Monoclonal Antibody - #BF8790
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
CP26; CP26B_HUMAN; CYP26A2; cyp26b1; Cytochrome P450 26A2; Cytochrome P450 26B1; Cytochrome P450 family 26 subfamily B polypeptide 1; Cytochrome P450 retinoic acid-inactivating 2; Cytochrome P450 retinoid metabolizing protein; Cytochrome P450 subfamily XXVIA, polypeptide 2; Cytochrome P450 subfamily XXVIB polypeptide 1; Cytochrome P450RAI-2; DKFZp686G0638; dol; EC 1.14.; fc21d03; MGC129613; P450 26A2; P450 retinoic acid inactivating 2; P450RAI 2; P450RAI2; Retinoic acid metabolizing cytochrome; Retinoic acid-metabolizing cytochrome; RHFCA; stocksteif; wu:fc21d03; wu:fc26h10; zgc:76999;
免疫原
- Q9NR63 CP26B_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLFEGLDLVSALATLAACLVSVTLLLAVSQQLWQLRWAATRDKSCKLPIPKGSMGFPLIGETGHWLLQGSGFQSSRREKYGNVFKTHLLGRPLIRVTGAENVRKILMGEHHLVSTEWPRSTRMLLGPNTVSNSIGDIHRNKRKVFSKIFSHEALESYLPKIQLVIQDTLRAWSSHPEAINVYQEAQKLTFRMAIRVLLGFSIPEEDLGHLFEVYQQFVDNVFSLPVDLPFSGYRRGIQARQILQKGLEKAIREKLQCTQGKDYLDALDLLIESSKEHGKEMTMQELKDGTLELIFAAYATTASASTSLIMQLLKHPTVLEKLRDELRAHGILHSGGCPCEGTLRLDTLSGLRYLDCVIKEVMRLFTPISGGYRTVLQTFELDGFQIPKGWSVMYSIRDTHDTAPVFKDVNVFDPDRFSQARSEDKDGRFHYLPFGGGVRTCLGKHLAKLFLKVLAVELASTSRFELATRTFPRITLVPVLHPVDGLSVKFFGLDSNQNEILPETEAMLSATV
PTMs - Q9NR63 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K275 | Ubiquitination | Uniprot | |
| T290 | Phosphorylation | Uniprot | |
| Y298 | Phosphorylation | Uniprot | |
| T317 | Phosphorylation | Uniprot | |
| K321 | Ubiquitination | Uniprot | |
| S462 | Phosphorylation | Uniprot | |
| T470 | Phosphorylation | Uniprot |
研究背景
Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA. Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Essential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints.
Has also a significant activity in oxidation of tazarotenic acid and may therefore metabolize that xenobiotic in vivo.
Endoplasmic reticulum membrane>Peripheral membrane protein. Microsome membrane>Peripheral membrane protein.
Highly expressed in brain, particularly in the cerebellum and pons.
Belongs to the cytochrome P450 family.
研究領域
· Metabolism > Metabolism of cofactors and vitamins > Retinol metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
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