AFfirm™ Flotillin 1 Mouse Monoclonal Antibody - #BF8826
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
FLOT 1; FLOT1; FLOT1_HUMAN; Flotillin-1; Flotillin1; Integral membrane component of caveolae; Reggie 2;
免疫原
- O75955 FLOT1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MFFTCGPNEAMVVSGFCRSPPVMVAGGRVFVLPCIQQIQRISLNTLTLNVKSEKVYTRHGVPISVTGIAQVKIQGQNKEMLAAACQMFLGKTEAEIAHIALETLEGHQRAIMAHMTVEEIYKDRQKFSEQVFKVASSDLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQKDARIGEAEAKRDAGIREAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQLQVAKTKQQIEEQRVQVQVVERAQQVAVQEQEIARREKELEARVRKPAEAERYKLERLAEAEKSQLIMQAEAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEKLPQVAEEISGPLTSANKITLVSSGSGTMGAAKVTGEVLDILTRLPESVERLTGVSISQVNHKPLRTA
PTMs - O75955 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S19 | Phosphorylation | Uniprot | |
| K51 | Ubiquitination | Uniprot | |
| K54 | Ubiquitination | Uniprot | |
| Y56 | Phosphorylation | P12931 (SRC) | Uniprot |
| K78 | Ubiquitination | Uniprot | |
| K122 | Ubiquitination | Uniprot | |
| K126 | Ubiquitination | Uniprot | |
| S128 | Phosphorylation | Uniprot | |
| Y149 | Phosphorylation | P12931 (SRC) | Uniprot |
| K152 | Ubiquitination | Uniprot | |
| Y160 | Phosphorylation | P06241 (FYN) | Uniprot |
| S163 | Phosphorylation | Uniprot | |
| K166 | Ubiquitination | Uniprot | |
| K174 | Ubiquitination | Uniprot | |
| K184 | Ubiquitination | Uniprot | |
| K195 | Ubiquitination | Uniprot | |
| K198 | Ubiquitination | Uniprot | |
| Y203 | Phosphorylation | Uniprot | |
| S205 | Phosphorylation | Uniprot | |
| K211 | Ubiquitination | Uniprot | |
| Y216 | Phosphorylation | Uniprot | |
| K220 | Methylation | Uniprot | |
| K220 | Ubiquitination | Uniprot | |
| Y223 | Phosphorylation | Uniprot | |
| Y238 | Phosphorylation | Uniprot | |
| K244 | Ubiquitination | Uniprot | |
| Y292 | Phosphorylation | Uniprot | |
| K293 | Ubiquitination | Uniprot | |
| K302 | Ubiquitination | Uniprot | |
| S315 | Phosphorylation | Uniprot | |
| K341 | Ubiquitination | Uniprot | |
| Y348 | Phosphorylation | Uniprot | |
| S383 | Phosphorylation | Uniprot | |
| S385 | Phosphorylation | Uniprot | |
| T387 | Phosphorylation | Uniprot | |
| K392 | Ubiquitination | Uniprot | |
| S407 | Phosphorylation | Uniprot | |
| K422 | Ubiquitination | Uniprot |
研究背景
May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.
Cell membrane>Peripheral membrane protein. Endosome. Membrane>Caveola>Peripheral membrane protein. Melanosome. Membrane raft.
Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Membrane-associated protein of caveola (By similarity).
Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2 (By similarity). Interacts with ECPAS.
Belongs to the band 7/mec-2 family. Flotillin subfamily.
研究領域
· Organismal Systems > Endocrine system > Insulin signaling pathway. (View pathway)
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