製品: UGT2B7 Mouse Monoclonal Antibody
カタログ: BF8841
タンパク質の説明: Mouse monoclonal antibody to UGT2B7
アプリケーション: WB
反応性: Human
予測: Mouse, Rat, Sheep
分子量: 55 kDa; 61kD(Calculated).
ユニプロット: P16662

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製品説明

ソース:
Mouse
アプリケーション:
WB 1:500-1:3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human
クローナリティ:
Monoclonal [AFfirm8841]
特異性:
UGT2B7 Mouse Monoclonal Antibody detects endogenous levels of total UGT2B7.
コンジュゲート:
Unconjugated.
精製:
Affinity-chromatography.
保存:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ/展開

UDP glucuronosyltransferase 2 family, member B7; 3 4 catechol estrogen specific; 3; 3,4 catechol estrogen specific UDPGT; 4-catechol estrogen-specific UDPGT; UD2B7_HUMAN; UDP glucuronosyltransferase 2 family, polypeptide B7; UDP glucuronosyltransferase 2 family polypeptide B7; UDP glucuronosyltransferase 2 family, member B9; UDP glucuronosyltransferase 2B7; UDP glucuronosyltransferase2 family, polypeptide B7; UDP glucuronyltransferase family 2 beta 7; UDP glycosyltransferase 2 family polypeptide B7; UDP-glucuronosyltransferase 2B7; UDP-glucuronosyltransferase 2B9; UDPGT; UDPGT 2B7; UDPGT 2B9; UDPGT2B7; UDPGTh 2; UDPGTh-2; UDPGTh2; UGT2B7; UGT2B9; UGTB2B9; uridine diphosphate glycosyltransferase 2 family, member B7; uridine diphosphate glycosyltransferase 2 family, member B9;

免疫原

免疫原:
Uniprot:
遺伝子(ID):
タンパク質配列:
MSVKWTSVILLIQLSFCFSSGNCGKVLVWAAEYSHWMNIKTILDELIQRGHEVTVLASSASILFDPNNSSALKIEIYPTSLTKTELENFIMQQIKRWSDLPKDTFWLYFSQVQEIMSIFGDITRKFCKDVVSNKKFMKKVQESRFDVIFADAIFPCSELLAELFNIPFVYSLSFSPGYTFEKHSGGFIFPPSYVPVVMSELTDQMTFMERVKNMIYVLYFDFWFEIFDMKKWDQFYSEVLGRPTTLSETMGKADVWLIRNSWNFQFPYPLLPNVDFVGGLHCKPAKPLPKEMEDFVQSSGENGVVVFSLGSMVSNMTEERANVIASALAQIPQKVLWRFDGNKPDTLGLNTRLYKWIPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFADQPDNIAHMKARGAAVRVDFNTMSSTDLLNALKRVINDPSYKENVMKLSRIQHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVIGFLLVCVATVIFIVTKCCLFCFWKFARKAKKGKND

PTMs - P16662 基板として

Site PTM Type Enzyme
N68 N-Glycosylation
Y236 Phosphorylation
K430 Acetylation
Y438 Phosphorylation P12931 (SRC)
R469 Methylation

研究背景

機能:

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Its unique specificity for 3,4-catechol estrogens and estriol suggests it may play an important role in regulating the level and activity of these potent and active estrogen metabolites. Is also active with androsterone, hyodeoxycholic acid and tetrachlorocatechol (in vitro).

細胞の位置付け:

Microsome membrane>Single-pass membrane protein. Endoplasmic reticulum membrane>Single-pass membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
タンパク質ファミリー:

Belongs to the UDP-glycosyltransferase family.

研究領域

· Human Diseases > Cancers: Overview > Chemical carcinogenesis.

· Metabolism > Carbohydrate metabolism > Pentose and glucuronate interconversions.

· Metabolism > Carbohydrate metabolism > Ascorbate and aldarate metabolism.

· Metabolism > Lipid metabolism > Steroid hormone biosynthesis.

· Metabolism > Metabolism of cofactors and vitamins > Retinol metabolism.

· Metabolism > Metabolism of cofactors and vitamins > Porphyrin and chlorophyll metabolism.

· Metabolism > Xenobiotics biodegradation and metabolism > Metabolism of xenobiotics by cytochrome P450.

· Metabolism > Xenobiotics biodegradation and metabolism > Drug metabolism - cytochrome P450.

· Metabolism > Xenobiotics biodegradation and metabolism > Drug metabolism - other enzymes.

· Metabolism > Global and overview maps > Metabolic pathways.

Restrictive clause

 

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For Research Use Only.
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