製品: TMOD1 Mouse Monoclonal Antibody
カタログ: BF8843
タンパク質の説明: Mouse monoclonal antibody to TMOD1
アプリケーション: WB
反応性: Human
予測: Mouse, Rat, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
分子量: 41 kDa; 41kD(Calculated).
ユニプロット: P28289

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製品説明

ソース:
Mouse
アプリケーション:
WB 1:500-1:3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human
クローナリティ:
Monoclonal [AFfirm8843]
特異性:
TMOD1 Mouse Monoclonal Antibody detects endogenous levels of total TMOD1.
コンジュゲート:
Unconjugated.
精製:
Affinity-chromatography.
保存:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ/展開

D9S57E; E Tmod; E tropomodulin; E-Tmod; Erythrocyte tropomodulin; ETMOD; MGC124125; MGC124126; OTTHUMP00000021743; TMOD; Tmod1; TMOD1 protein; TMOD1_HUMAN; Tropomodulin 1; Tropomodulin-1;

免疫原

免疫原:
Uniprot:
遺伝子(ID):
発現特異性:
P28289 TMOD1_HUMAN:

Highly expressed in the erythrocyte, heart and skeletal muscle.

タンパク質配列:
MSYRRELEKYRDLDEDEILGALTEEELRTLENELDELDPDNALLPAGLRQKDQTTKAPTGPFKREELLDHLEKQAKEFKDREDLVPYTGEKRGKVWVPKQKPLDPVLESVTLEPELEEALANASDAELCDIAAILGMHTLMSNQQYYQALSSSSIMNKEGLNSVIKPTQYKPVPDEEPNSTDVEETLERIKNNDPKLEEVNLNNIRNIPIPTLKAYAEALKENSYVKKFSIVGTRSNDPVAYALAEMLKENKVLKTLNVESNFISGAGILRLVEALPYNTSLVEMKIDNQSQPLGNKVEMEIVSMLEKNATLLKFGYHFTQQGPRLRASNAMMNNNDLVRKRRLADLTGPIIPKCRSGV

PTMs - P28289 基板として

Site PTM Type Enzyme
S2 Phosphorylation Q96QT4 (TRPM7)
Y3 Phosphorylation
Y10 Phosphorylation
T23 Phosphorylation
T54 Phosphorylation Q96QT4 (TRPM7)
Y87 Phosphorylation
Y225 Phosphorylation
T234 Phosphorylation
S236 Phosphorylation
Y242 Phosphorylation
Y278 Phosphorylation
S329 Phosphorylation

研究背景

機能:

Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus.

細胞の位置付け:

Cytoplasm>Cytoskeleton.
Note: In myofibrils with sarcomeric structure, localizes to the pointed end of actin thin filaments (PubMed:25250574).

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Highly expressed in the erythrocyte, heart and skeletal muscle.

サブユニット構造:

Binds to the N-terminus of isoforms 2/3 of TPM3 and to actin.

タンパク質ファミリー:

Belongs to the tropomodulin family.

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