AFfirm™ BCL11A Mouse Monoclonal Antibody - #BF8875
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
2810047E18Rik; B cell CLL/lymphoma 11A (zinc finger protein); B cell CLL/lymphoma 11A (zinc finger protein) isoform 2; B-cell CLL/lymphoma 11A; B-cell lymphoma/leukemia 11A; BC11A_HUMAN; BCL-11A; BCL11A; BCL11A B cell CLL/lymphoma 11A (zinc finger protein) isoform 1; BCL11A L; BCL11A S; BCL11A XL; BCL11a-M; BCL11AL; BCL11AS; BCL11AXL; C2H2 type zinc finger protein; COUP TF interacting protein 1; COUP-TF-interacting protein 1; CTIP1; CTIP1, mouse, homolog of; D930021L15Rik; Ecotropic viral integration site 9; Ecotropic viral integration site 9 homolog; Ecotropic viral integration site 9 protein; Ecotropic viral integration site 9 protein homolog; EVI-9; Evi9; Evi9, mouse, homolog of; FLJ10173; FLJ34997; HBFQTL5; KIAA1809; mKIAA1809; OTTHUMP00000159788; OTTHUMP00000159789; OTTHUMP00000201250; OTTHUMP00000202084; Zinc finger protein 856; ZNF856;
免疫原
Expressed at high levels in brain, spleen thymus, bone marrow and testis. Expressed in CD34-positive myeloid precursor cells, B-cells, monocytes and megakaryocytes. Expression is tightly regulated during B-cell development.
- Q9H165 BC11A_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSRRKQGKPQHLSKREFSPEPLEAILTDDEPDHGPLGAPEGDHDLLTCGQCQMNFPLGDILIFIEHKRKQCNGSLCLEKAVDKPPSPSPIEMKKASNPVEVGIQVTPEDDDCLSTSSRGICPKQEHIADKLLHWRGLSSPRSAHGALIPTPGMSAEYAPQGICKDEPSSYTCTTCKQPFTSAWFLLQHAQNTHGLRIYLESEHGSPLTPRVGIPSGLGAECPSQPPLHGIHIADNNPFNLLRIPGSVSREASGLAEGRFPPTPPLFSPPPRHHLDPHRIERLGAEEMALATHHPSAFDRVLRLNPMAMEPPAMDFSRRLRELAGNTSSPPLSPGRPSPMQRLLQPFQPGSKPPFLATPPLPPLQSAPPPSQPPVKSKSCEFCGKTFKFQSNLVVHRRSHTGEKPYKCNLCDHACTQASKLKRHMKTHMHKSSPMTVKSDDGLSTASSPEPGTSDLVGSASSALKSVVAKFKSENDPNLIPENGDEEEEEDDEEEEEEEEEEEEELTESERVDYGFGLSLEAARHHENSSRGAVVGVGDESRALPDVMQGMVLSSMQHFSEAFHQVLGEKHKRGHLAEAEGHRDTCDEDSVAGESDRIDDGTVNGRGCSPGESASGGLSKKLLLGSPSSLSPFSKRIKLEKEFDLPPAAMPNTENVYSQWLAGYAASRQLKDPFLSFGDSRQSPFASSSEHSSENGSLRFSTPPGELDGGISGRSGTGSGGSTPHISGPGPGRPSSKEGRRSDTCEYCGKVFKNCSNLTVHRRSHTGERPYKCELCNYACAQSSKLTRHMKTHGQVGKDVYKCEICKMPFSVYSTLEKHMKKWHSDRVLNNDIKTE
PTMs - Q9H165 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S86 | Phosphorylation | Uniprot | |
| S88 | Phosphorylation | Uniprot | |
| K123 | Ubiquitination | Uniprot | |
| K130 | Ubiquitination | Uniprot | |
| T150 | Phosphorylation | Uniprot | |
| Y198 | Phosphorylation | Uniprot | |
| S201 | Phosphorylation | Uniprot | |
| S205 | Phosphorylation | Uniprot | |
| T208 | Phosphorylation | Uniprot | |
| T262 | Phosphorylation | Uniprot | |
| S267 | Phosphorylation | Uniprot | |
| S328 | Phosphorylation | Uniprot | |
| S332 | Phosphorylation | Uniprot | |
| T357 | Phosphorylation | Uniprot | |
| K377 | Ubiquitination | Uniprot | |
| K384 | Acetylation | Uniprot | |
| K384 | Ubiquitination | Uniprot | |
| T400 | Phosphorylation | Uniprot | |
| T426 | Phosphorylation | Uniprot | |
| S432 | Phosphorylation | Uniprot | |
| T435 | Phosphorylation | Uniprot | |
| S446 | Phosphorylation | Uniprot | |
| S447 | Phosphorylation | Uniprot | |
| T584 | Phosphorylation | Uniprot | |
| S589 | Phosphorylation | Uniprot | |
| S594 | Phosphorylation | Uniprot | |
| S608 | Phosphorylation | Uniprot | |
| S612 | Phosphorylation | Uniprot | |
| S618 | Phosphorylation | Uniprot | |
| K619 | Ubiquitination | Uniprot | |
| K620 | Ubiquitination | Uniprot | |
| S625 | Phosphorylation | Uniprot | |
| S627 | Phosphorylation | Uniprot | |
| S628 | Phosphorylation | Uniprot | |
| S630 | Phosphorylation | Uniprot | |
| S633 | Phosphorylation | Uniprot | |
| K634 | Ubiquitination | Uniprot | |
| K670 | Ubiquitination | Uniprot | |
| T701 | Phosphorylation | Uniprot | |
| S714 | Phosphorylation | Uniprot | |
| S718 | Phosphorylation | Uniprot | |
| S721 | Phosphorylation | Uniprot | |
| T722 | Phosphorylation | Uniprot | |
| K736 | Ubiquitination | Uniprot | |
| S741 | Phosphorylation | Uniprot | |
| T743 | Phosphorylation | Uniprot | |
| K749 | Ubiquitination | Uniprot | |
| K752 | Ubiquitination | Uniprot | |
| S755 | Phosphorylation | Uniprot | |
| T765 | Phosphorylation | Uniprot | |
| K771 | Ubiquitination | Uniprot | |
| K784 | Ubiquitination | Uniprot |
研究背景
Transcription factor associated with the BAF SWI/SNF chromatin remodeling complex (By similarity). Repressor of fetal hemoglobin (HbF) level. Involved in brain development. May play a role in hematopoiesis. Essential factor in lymphopoiesis required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of ARP1 (By similarity).
Sumoylated with SUMO1.
Cytoplasm. Nucleus.
Note: Associates with the nuclear body. Colocalizes with SUMO1 and SENP2 in nuclear speckles (By similarity).
Cytoplasm. Nucleus.
Note: Predominantly localized in the nucleus in nuclear paraspeckles.
Cytoplasm. Nucleus.
Note: Predominantly localized in the cytoplasm in the absence of interaction with isoform 1 and isoform 2. In presence of isoform 1 or isoform 2, translocates from the cytoplasm into nuclear paraspeckles.
Expressed at high levels in brain, spleen thymus, bone marrow and testis. Expressed in CD34-positive myeloid precursor cells, B-cells, monocytes and megakaryocytes. Expression is tightly regulated during B-cell development.
Interacts with TFCOUP1, PIAS3, ARP1 and EAR2 (By similarity). Isoform 1, isoform 2 and isoform 3 form homodimers and heterodimers. Isoform 2 interacts with TBR1.
The N-terminus is involved in protein dimerization and in transactivation of transcription.
The C-terminus of isoform 2 is necessary for isoform 2 interaction with TBR1.
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