AFfirm™ Centaurin alpha 1 Mouse Monoclonal Antibody - #BF8889

製品: Centaurin alpha 1 Mouse Monoclonal Antibody
カタログ: BF8889
タンパク質の説明: Mouse monoclonal antibody to Centaurin alpha 1
アプリケーション: WB
反応性: Human
予測: Mouse, Rat
分子量: 40-50kD; 43kD(Calculated).
ユニプロット: O75689

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関連ダウンロード
MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Mouse
アプリケーション:
WB 1:500-1:3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human
クローナリティ:
Monoclonal [AFfirm8889]
特異性:
Centaurin alpha 1 Mouse Monoclonal Antibody detects endogenous levels of total Centaurin alpha 1.
コンジュゲート:
Unconjugated.
精製:
Affinity-chromatography.
保存:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

ArfGAP with dual PH domains 1; CENTA 1; CENTA1; Centaurin alpha; GCS1L; p42IP4; Putative MAPK activating protein PM25;

免疫原

免疫原:

A synthesized peptide derived from Human Centaurin alpha 1.

Uniprot:

O75689(ADAP1_HUMAN) >>Visit HPA database.

遺伝子(ID):
ADAP1(11033)
発現特異性:
O75689 ADAP1_HUMAN:

Expressed at highest levels in brain and at lower levels in peripheral blood leukocytes.

タンパク質配列:
MAKERRRAVLELLQRPGNARCADCGAPDPDWASYTLGVFICLSCSGIHRNIPQVSKVKSVRLDAWEEAQVEFMASHGNDAARARFESKVPSFYYRPTPSDCQLLREQWIRAKYERQEFIYPEKQEPYSAGYREGFLWKRGRDNGQFLSRKFVLTEREGALKYFNRNDAKEPKAVMKIEHLNATFQPAKIGHPHGLQVTYLKDNSTRNIFIYHEDGKEIVDWFNALRAARFHYLQVAFPGAGDADLVPKLSRNYLKEGYMEKTGPKQTEGFRKRWFTMDDRRLMYFKDPLDAFARGEVFIGSKESGYTVLHGFPPSTQGHHWPHGITIVTPDRKFLFACETESDQREWVAAFQKAVDRPMLPQEYAVEAHFKHKP

研究背景

機能:

GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4).

PTMs:

Phosphorylated by PRKCA, PRKCI, PRKCZ and PRKD1 in vitro.

細胞の位置付け:

Nucleus. Cytoplasm.
Note: Recruited to the plasma membrane upon epidermal growth factor-dependent activation of phosphatidylinositol 4,5-diphosphate (PtdInsP2) 3-kinase.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Expressed at highest levels in brain and at lower levels in peripheral blood leukocytes.

サブユニット構造:

Interacts with PRKCA, PRKCI and PRKCZ. Interacts with the N-terminal region of PRKD1.

Restrictive clause

 

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