製品: SENP2 Mouse Monoclonal Antibody
カタログ: BF8910
タンパク質の説明: Mouse monoclonal antibody to SENP2
アプリケーション: WB
反応性: Human
予測: Human
分子量: 68kD(Calculated).
ユニプロット: Q9HC62

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製品説明

ソース:
Mouse
アプリケーション:
WB 1:500-1:3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human
クローナリティ:
Monoclonal [AFfirm8910]
特異性:
SENP2 Mouse Monoclonal Antibody detects endogenous levels of total SENP2.
コンジュゲート:
Unconjugated.
精製:
Affinity-chromatography.
保存:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ/展開

Axam2; DKFZp762A2316; KIAA1331; Senp2; SENP2_HUMAN; Sentrin specific protease 2; Sentrin-specific protease 2; Sentrin/SUMO specific protease SENP2; Sentrin/SUMO-specific protease SENP2; SMT3 specific isopeptidase 2; SMT3-specific isopeptidase 2; Smt3ip2; SUMO1/sentrin/SMT3 specific peptidase 2;

免疫原

免疫原:

A synthesized peptide derived from human SENP2.

Uniprot:
遺伝子(ID):
タンパク質配列:
MYRWLVRILGTIFRFCDRSVPPARALLKRRRSDSTLFSTVDTDEIPAKRPRLDCFIHQVKNSLYNAASLFGFPFQLTTKPMVTSACNGTRNVAPSGEVFSNSSSCELTGSGSWNNMLKLGNKSPNGISDYPKIRVTVTRDQPRRVLPSFGFTLNSEGCNRRPGGRRHSKGNPESSLMWKPQEQAVTEMISEESGKGLRRPHCTVEEGVQKEEREKYRKLLERLKESGHGNSVCPVTSNYHSSQRSQMDTLKTKGWGEEQNHGVKTTQFVPKQYRLVETRGPLCSLRSEKRCSKGKITDTETMVGIRFENESRRGYQLEPDLSEEVSARLRLGSGSNGLLRRKVSIIETKEKNCSGKERDRRTDDLLELTEDMEKEISNALGHGPQDEILSSAFKLRITRGDIQTLKNYHWLNDEVINFYMNLLVERNKKQGYPALHVFSTFFYPKLKSGGYQAVKRWTKGVNLFEQEIILVPIHRKVHWSLVVIDLRKKCLKYLDSMGQKGHRICEILLQYLQDESKTKRNSDLNLLEWTHHSMKPHEIPQQLNGSDCGMFTCKYADYISRDKPITFTQHQMPLFRKKMVWEILHQQLL

PTMs - Q9HC62 基板として

Site PTM Type Enzyme
S32 Phosphorylation
S34 Phosphorylation
T35 Phosphorylation
S123 Phosphorylation
Y130 Phosphorylation
S168 Phosphorylation
Y216 Phosphorylation
K224 Ubiquitination
S231 Phosphorylation
Y239 Phosphorylation
K253 Acetylation
K264 Acetylation
K271 Acetylation
K271 Ubiquitination
S284 Phosphorylation
S287 Phosphorylation
S292 Phosphorylation
S333 Phosphorylation
S344 Phosphorylation O14757 (CHEK1)
T369 Phosphorylation Q15418 (RPS6KA1)
K455 Ubiquitination
Y493 Phosphorylation
S496 Phosphorylation
Y558 Phosphorylation

研究背景

機能:

Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Deconjugates SUMO2 from MTA1. Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB.

PTMs:

Polyubiquitinated; which leads to proteasomal degradation.

細胞の位置付け:

Nucleus>Nuclear pore complex. Nucleus membrane>Peripheral membrane protein>Nucleoplasmic side. Cytoplasm.
Note: Shuttles between cytoplasm and nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
サブユニット構造:

Binds to SUMO2 and SUMO3 (By similarity). Interacts with the C-terminal domain of NUP153 via its N-terminus. Interacts with MTA1.

タンパク質ファミリー:

The N-terminus is necessary and sufficient for nuclear envelope targeting.

Belongs to the peptidase C48 family.

研究領域

· Environmental Information Processing > Signal transduction > Wnt signaling pathway.   (View pathway)

· Genetic Information Processing > Translation > RNA transport.

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