AFfirm™ SENP2 Mouse Monoclonal Antibody - #BF8910
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
Axam2; DKFZp762A2316; KIAA1331; Senp2; SENP2_HUMAN; Sentrin specific protease 2; Sentrin-specific protease 2; Sentrin/SUMO specific protease SENP2; Sentrin/SUMO-specific protease SENP2; SMT3 specific isopeptidase 2; SMT3-specific isopeptidase 2; Smt3ip2; SUMO1/sentrin/SMT3 specific peptidase 2;
免疫原
A synthesized peptide derived from human SENP2.
- Q9HC62 SENP2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MYRWLVRILGTIFRFCDRSVPPARALLKRRRSDSTLFSTVDTDEIPAKRPRLDCFIHQVKNSLYNAASLFGFPFQLTTKPMVTSACNGTRNVAPSGEVFSNSSSCELTGSGSWNNMLKLGNKSPNGISDYPKIRVTVTRDQPRRVLPSFGFTLNSEGCNRRPGGRRHSKGNPESSLMWKPQEQAVTEMISEESGKGLRRPHCTVEEGVQKEEREKYRKLLERLKESGHGNSVCPVTSNYHSSQRSQMDTLKTKGWGEEQNHGVKTTQFVPKQYRLVETRGPLCSLRSEKRCSKGKITDTETMVGIRFENESRRGYQLEPDLSEEVSARLRLGSGSNGLLRRKVSIIETKEKNCSGKERDRRTDDLLELTEDMEKEISNALGHGPQDEILSSAFKLRITRGDIQTLKNYHWLNDEVINFYMNLLVERNKKQGYPALHVFSTFFYPKLKSGGYQAVKRWTKGVNLFEQEIILVPIHRKVHWSLVVIDLRKKCLKYLDSMGQKGHRICEILLQYLQDESKTKRNSDLNLLEWTHHSMKPHEIPQQLNGSDCGMFTCKYADYISRDKPITFTQHQMPLFRKKMVWEILHQQLL
PTMs - Q9HC62 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S32 | Phosphorylation | Uniprot | |
| S34 | Phosphorylation | Uniprot | |
| T35 | Phosphorylation | Uniprot | |
| S123 | Phosphorylation | Uniprot | |
| Y130 | Phosphorylation | Uniprot | |
| S168 | Phosphorylation | Uniprot | |
| Y216 | Phosphorylation | Uniprot | |
| K224 | Ubiquitination | Uniprot | |
| S231 | Phosphorylation | Uniprot | |
| Y239 | Phosphorylation | Uniprot | |
| K253 | Acetylation | Uniprot | |
| K264 | Acetylation | Uniprot | |
| K271 | Acetylation | Uniprot | |
| K271 | Ubiquitination | Uniprot | |
| S284 | Phosphorylation | Uniprot | |
| S287 | Phosphorylation | Uniprot | |
| S292 | Phosphorylation | Uniprot | |
| S333 | Phosphorylation | Uniprot | |
| S344 | Phosphorylation | O14757 (CHEK1) | Uniprot |
| T369 | Phosphorylation | Q15418 (RPS6KA1) | Uniprot |
| K455 | Ubiquitination | Uniprot | |
| Y493 | Phosphorylation | Uniprot | |
| S496 | Phosphorylation | Uniprot | |
| Y558 | Phosphorylation | Uniprot |
研究背景
Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Deconjugates SUMO2 from MTA1. Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB.
Polyubiquitinated; which leads to proteasomal degradation.
Nucleus>Nuclear pore complex. Nucleus membrane>Peripheral membrane protein>Nucleoplasmic side. Cytoplasm.
Note: Shuttles between cytoplasm and nucleus.
Binds to SUMO2 and SUMO3 (By similarity). Interacts with the C-terminal domain of NUP153 via its N-terminus. Interacts with MTA1.
The N-terminus is necessary and sufficient for nuclear envelope targeting.
Belongs to the peptidase C48 family.
研究領域
· Environmental Information Processing > Signal transduction > Wnt signaling pathway. (View pathway)
· Genetic Information Processing > Translation > RNA transport.
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