AFfirm™ VAV1 Mouse Monoclonal Antibody - #BF8922
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
Oncogene vav; p95Vav; Proto-oncogene vav; Protooncogene vav; VAV 1; VAV 1 oncogene; VAV; Vav proto oncogene; VAV_HUMAN; VAV1;
免疫原
- P15498 VAV_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNLLPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQIDDTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHFLKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAAREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEAMEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHYGRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLHSFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFEMAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCRASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVFQEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWFPCNRVKPYVHGPPQDLSVHLWYAGPMERAGAESILANRSDGTFLVRQRVKDAAEFAISIKYNVEVKHIKIMTAEGLYRITEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEPEKRTISRPAVGSTKYFGTAKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRVGWFPANYVEEDYSEYC
PTMs - P15498 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K73 | Ubiquitination | Uniprot | |
| K85 | Ubiquitination | Uniprot | |
| K89 | Ubiquitination | Uniprot | |
| Y110 | Phosphorylation | Uniprot | |
| S113 | Phosphorylation | Uniprot | |
| Y142 | Phosphorylation | P06239 (LCK) | Uniprot |
| Y160 | Phosphorylation | P06239 (LCK) | Uniprot |
| Y174 | Phosphorylation | P43405 (SYK) , P06239 (LCK) | Uniprot |
| S180 | Phosphorylation | Uniprot | |
| K188 | Ubiquitination | Uniprot | |
| Y192 | Phosphorylation | Uniprot | |
| K194 | Acetylation | Uniprot | |
| K194 | Ubiquitination | Uniprot | |
| K208 | Ubiquitination | Uniprot | |
| S215 | Phosphorylation | Uniprot | |
| K222 | Acetylation | Uniprot | |
| K222 | Ubiquitination | Uniprot | |
| K252 | Acetylation | Uniprot | |
| K255 | Ubiquitination | Uniprot | |
| Y267 | Phosphorylation | P00519 (ABL1) | Uniprot |
| Y280 | Phosphorylation | Uniprot | |
| S285 | Phosphorylation | Uniprot | |
| K292 | Ubiquitination | Uniprot | |
| K307 | Ubiquitination | Uniprot | |
| K335 | Ubiquitination | Uniprot | |
| K345 | Acetylation | Uniprot | |
| K345 | Ubiquitination | Uniprot | |
| K353 | Ubiquitination | Uniprot | |
| K374 | Ubiquitination | Uniprot | |
| S396 | Phosphorylation | Uniprot | |
| K404 | Ubiquitination | Uniprot | |
| K410 | Ubiquitination | Uniprot | |
| K429 | Ubiquitination | Uniprot | |
| K435 | Ubiquitination | Uniprot | |
| K444 | Ubiquitination | Uniprot | |
| K465 | Ubiquitination | Uniprot | |
| K487 | Acetylation | Uniprot | |
| Y541 | Phosphorylation | Uniprot | |
| K555 | Ubiquitination | Uniprot | |
| T574 | Phosphorylation | Uniprot | |
| K576 | Ubiquitination | Uniprot | |
| K588 | Ubiquitination | Uniprot | |
| Y603 | Phosphorylation | Uniprot | |
| K629 | Ubiquitination | Uniprot | |
| S683 | Phosphorylation | Uniprot | |
| K700 | Ubiquitination | Uniprot | |
| K716 | Acetylation | Uniprot | |
| K716 | Ubiquitination | Uniprot | |
| K732 | Acetylation | Uniprot | |
| K732 | Ubiquitination | Uniprot | |
| K733 | Acetylation | Uniprot | |
| Y745 | Phosphorylation | Uniprot | |
| K751 | Ubiquitination | Uniprot | |
| K755 | Ubiquitination | Uniprot | |
| K766 | Ubiquitination | Uniprot | |
| K770 | Ubiquitination | Uniprot | |
| S774 | Phosphorylation | Uniprot | |
| S780 | Phosphorylation | Uniprot | |
| K782 | Ubiquitination | Uniprot | |
| Y783 | Phosphorylation | Uniprot | |
| T786 | Phosphorylation | Uniprot | |
| K788 | Ubiquitination | Uniprot | |
| Y791 | Phosphorylation | Uniprot | |
| K804 | Ubiquitination | Uniprot | |
| K810 | Ubiquitination | Uniprot | |
| K815 | Ubiquitination | Uniprot | |
| Y826 | Phosphorylation | Uniprot | |
| Y836 | Phosphorylation | Uniprot | |
| Y841 | Phosphorylation | Uniprot | |
| S842 | Phosphorylation | Uniprot | |
| Y844 | Phosphorylation | Uniprot |
研究背景
Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.
Phosphorylated on tyrosine residues by HCK in response to IFNG and bacterial lipopolysaccharide (LPS) (By similarity). Phosphorylated by FYN.
Widely expressed in hematopoietic cells but not in other cell types.
Interacts with SHB. Interacts with APS, GRB2, GRB3, DOCK2, SLA, TEC and ZNF655/VIK. Interacts with SIAH2; without leading to its degradation. Associates with BLNK, PLCG1, GRB2 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with CBLB; which inhibits tyrosine phosphorylation and down-regulates activity. May interact with CCPG1. Interacts with CLNK. Interacts with THEMIS2 (By similarity). Interacts with NEK3 and this interaction is prolactin-dependent. Interacts with ITK. Interacts with PTK2B/PYK2 (By similarity). Interacts with HCK. Interacts with PTK2B/PYK2. Interacts (via SH2 domain) with SYK. Interacts with ANKRD54. Interacts with CD6 (By similarity).
The DH domain is involved in interaction with CCPG1.
研究領域
· Cellular Processes > Cellular community - eukaryotes > Focal adhesion. (View pathway)
· Cellular Processes > Cell motility > Regulation of actin cytoskeleton. (View pathway)
· Environmental Information Processing > Signal transduction > cAMP signaling pathway. (View pathway)
· Organismal Systems > Immune system > Chemokine signaling pathway. (View pathway)
· Organismal Systems > Immune system > Natural killer cell mediated cytotoxicity. (View pathway)
· Organismal Systems > Immune system > T cell receptor signaling pathway. (View pathway)
· Organismal Systems > Immune system > B cell receptor signaling pathway. (View pathway)
· Organismal Systems > Immune system > Fc epsilon RI signaling pathway. (View pathway)
· Organismal Systems > Immune system > Fc gamma R-mediated phagocytosis. (View pathway)
· Organismal Systems > Immune system > Leukocyte transendothelial migration. (View pathway)
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.