AFfirm™ STAT5B Mouse Monoclonal Antibody - #BF8924
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
Signal transducer and activator of transcription 5B; STA5B_HUMAN; STAT5; Stat5b; Transcription factor STAT5B;
免疫原
- P51692 STA5B_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAVWIQAQQLQGEALHQMQALYGQHFPIEVRHYLSQWIESQAWDSVDLDNPQENIKATQLLEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQNTYDRCPMELVRCIRHILYNEQRLVREANNGSSPAGSLADAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESLRIQAQFGPLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRNDYSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRSDRRGAESVTEEKFTILFESQFSVGGNELVFQVKTLSLPVVVIVHGSQDNNATATVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNNSSSHLEDYSGLSVSWSQFNRENLPGRNYTFWQWFDGVMEVLKKHLKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSQERMFWNLMPFTTRDFSIRSLADRLGDLNYLIYVFPDRPKDEVYSKYYTPVPCESATAKAVDGYVKPQIKQVVPEFVNASADAGGGSATYMDQAPSPAVCPQAHYNMYPQNPDSVLDTDGDFDLEDTMDVARRVEELLGRPMDSQWIPHAQS
PTMs - P51692 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K56 | Sumoylation | Uniprot | |
| K70 | Ubiquitination | Uniprot | |
| K71 | Ubiquitination | Uniprot | |
| K84 | Acetylation | Uniprot | |
| K84 | Ubiquitination | Uniprot | |
| K86 | Ubiquitination | Uniprot | |
| Y90 | Phosphorylation | Uniprot | |
| T92 | Phosphorylation | Uniprot | |
| Y98 | Phosphorylation | Uniprot | |
| Y114 | Phosphorylation | Uniprot | |
| S127 | Phosphorylation | Uniprot | |
| S128 | Phosphorylation | Uniprot | |
| S132 | Phosphorylation | Uniprot | |
| K140 | Ubiquitination | Uniprot | |
| K163 | Ubiquitination | Uniprot | |
| K164 | Ubiquitination | Uniprot | |
| S193 | Phosphorylation | Uniprot | |
| K207 | Ubiquitination | Uniprot | |
| K232 | Ubiquitination | Uniprot | |
| K235 | Ubiquitination | Uniprot | |
| K242 | Ubiquitination | Uniprot | |
| T245 | Phosphorylation | Uniprot | |
| K256 | Sumoylation | Uniprot | |
| K256 | Ubiquitination | Uniprot | |
| K336 | Sumoylation | Uniprot | |
| K343 | Ubiquitination | Uniprot | |
| K359 | Ubiquitination | Uniprot | |
| K370 | Ubiquitination | Uniprot | |
| T372 | Phosphorylation | Uniprot | |
| S375 | Phosphorylation | Uniprot | |
| K380 | Ubiquitination | Uniprot | |
| K384 | Acetylation | Uniprot | |
| K384 | Sumoylation | Uniprot | |
| K384 | Ubiquitination | Uniprot | |
| Y392 | Phosphorylation | Uniprot | |
| K516 | Sumoylation | Uniprot | |
| K516 | Ubiquitination | Uniprot | |
| K527 | Ubiquitination | Uniprot | |
| K583 | Ubiquitination | Uniprot | |
| K586 | Ubiquitination | Uniprot | |
| S655 | Phosphorylation | Uniprot | |
| Y665 | Phosphorylation | Uniprot | |
| Y668 | Phosphorylation | Uniprot | |
| K675 | Sumoylation | Uniprot | |
| K675 | Ubiquitination | Uniprot | |
| Y679 | Phosphorylation | P12931 (SRC) | Uniprot |
| K681 | Acetylation | Uniprot | |
| K681 | Ubiquitination | Uniprot | |
| Y682 | Phosphorylation | Uniprot | |
| Y683 | Phosphorylation | Uniprot | |
| T684 | Phosphorylation | Uniprot | |
| C688 | S-Nitrosylation | Uniprot | |
| T692 | Phosphorylation | Uniprot | |
| K694 | Acetylation | Uniprot | |
| K694 | Ubiquitination | Uniprot | |
| Y699 | Phosphorylation | Q13882 (PTK6) , P06213 (INSR) , P08631 (HCK) , P12931 (SRC) , P00533 (EGFR) , O60674 (JAK2) | Uniprot |
| K701 | Acetylation | Uniprot | |
| K701 | Sumoylation | Uniprot | |
| K701 | Ubiquitination | Uniprot | |
| K705 | Acetylation | Uniprot | |
| Y725 | Phosphorylation | P00533 (EGFR) | Uniprot |
| S731 | Phosphorylation | Uniprot | |
| Y740 | Phosphorylation | P00533 (EGFR) | Uniprot |
| Y743 | Phosphorylation | P00533 (EGFR) | Uniprot |
| S787 | Phosphorylation | Uniprot |
研究背景
Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation.
Tyrosine phosphorylated in response to signaling via activated KIT, resulting in translocation to the nucleus. Tyrosine phosphorylated in response to signaling via activated FLT3; wild-type FLT3 results in much weaker phosphorylation than constitutively activated mutant FLT3. Alternatively, can be phosphorylated by JAK2. Phosphorylation at Tyr-699 by PTK6 or HCK leads to an increase of its transcriptional activity.
Cytoplasm. Nucleus.
Note: Translocated into the nucleus in response to phosphorylation.
Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 (By similarity). Interacts with NCOA1. Interacts with NMI. Interacts with SOCS7. Interacts (via SH2 domain) with INSR. Interacts with CPEB3; this inhibits STAT5B-mediated transcriptional activation.
Belongs to the transcription factor STAT family.
研究領域
· Cellular Processes > Cell growth and death > Necroptosis. (View pathway)
· Environmental Information Processing > Signal transduction > ErbB signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Jak-STAT signaling pathway. (View pathway)
· Human Diseases > Infectious diseases: Viral > Hepatitis B.
· Human Diseases > Infectious diseases: Viral > Measles.
· Human Diseases > Infectious diseases: Viral > HTLV-I infection.
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
· Human Diseases > Cancers: Overview > Viral carcinogenesis.
· Human Diseases > Cancers: Specific types > Chronic myeloid leukemia. (View pathway)
· Human Diseases > Cancers: Specific types > Acute myeloid leukemia. (View pathway)
· Human Diseases > Cancers: Specific types > Non-small cell lung cancer. (View pathway)
· Organismal Systems > Immune system > Chemokine signaling pathway. (View pathway)
· Organismal Systems > Immune system > Th1 and Th2 cell differentiation. (View pathway)
· Organismal Systems > Immune system > Th17 cell differentiation. (View pathway)
· Organismal Systems > Endocrine system > Prolactin signaling pathway. (View pathway)
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