AFfirm™ P Glycoprotein 1（MDR1） Mouse Monoclonal Antibody - #BF8972
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
ABC20; ABCB1; ATP binding cassette, sub family B (MDR/TAP), member 1; ATP-binding cassette sub-family B member 1; CD243; CLCS; Colchicin sensitivity; Doxorubicin resistance; GP170; MDR1; MDR1_HUMAN; Multidrug resistance 1; Multidrug resistance protein 1; P glycoprotein 1; P gp; P-glycoprotein 1; PGY1;
免疫原
- P08183 MDR1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNLEDLMSNITNRSDINDTGFFMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAADESKSEIDALEMSSNDSRSSLIRKRSTRRSVRGSQAQDRKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTKRQ
PTMs - P08183 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S23 | Phosphorylation | Uniprot | |
| T263 | Phosphorylation | Uniprot | |
| K271 | Ubiquitination | Uniprot | |
| K279 | Ubiquitination | Uniprot | |
| K367 | Ubiquitination | Uniprot | |
| K372 | Ubiquitination | Uniprot | |
| K380 | Ubiquitination | Uniprot | |
| K384 | Acetylation | Uniprot | |
| K389 | Ubiquitination | Uniprot | |
| K405 | Sumoylation | Uniprot | |
| K408 | Sumoylation | Uniprot | |
| K411 | Ubiquitination | Uniprot | |
| T422 | Phosphorylation | Uniprot | |
| T496 | Phosphorylation | Uniprot | |
| K515 | Ubiquitination | Uniprot | |
| K519 | Ubiquitination | Uniprot | |
| T522 | Phosphorylation | Uniprot | |
| K536 | Ubiquitination | Uniprot | |
| K617 | Ubiquitination | Uniprot | |
| K619 | Ubiquitination | Uniprot | |
| S644 | Phosphorylation | Uniprot | |
| S658 | Phosphorylation | Uniprot | |
| S660 | Phosphorylation | Uniprot | |
| S661 | Phosphorylation | P17252 (PRKCA) | Uniprot |
| S667 | Phosphorylation | P17612 (PRKACA) , P17252 (PRKCA) | Uniprot |
| S671 | Phosphorylation | P17252 (PRKCA) , P17612 (PRKACA) | Uniprot |
| S675 | Phosphorylation | Uniprot | |
| S683 | Phosphorylation | P17612 (PRKACA) | Uniprot |
| T684 | Phosphorylation | Uniprot | |
| S696 | Phosphorylation | Uniprot | |
| K826 | Ubiquitination | Uniprot | |
| K915 | Ubiquitination | Uniprot | |
| T1015 | Phosphorylation | Uniprot | |
| T1023 | Phosphorylation | Uniprot | |
| T1030 | Phosphorylation | Uniprot | |
| K1062 | Ubiquitination | Uniprot | |
| Y1087 | Phosphorylation | Uniprot | |
| K1093 | Ubiquitination | Uniprot | |
| K1099 | Ubiquitination | Uniprot | |
| K1102 | Methylation | Uniprot | |
| K1172 | Ubiquitination | Uniprot | |
| K1181 | Ubiquitination | Uniprot | |
| K1212 | Ubiquitination | Uniprot | |
| Y1267 | Phosphorylation | Uniprot | |
| S1269 | Phosphorylation | Uniprot |
研究背景
Translocates drugs and phospholipids across the membrane. Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins. Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Cell membrane>Multi-pass membrane protein. Apical cell membrane.
Expressed in liver, kidney, small intestine and brain.
Interacts with PSMB5. Finds in a complex with ABCB1, TFPI2 and PPP2R3C; leading to the dephosphorylation of ABCB1.
Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
研究領域
· Environmental Information Processing > Membrane transport > ABC transporters.
· Human Diseases > Cancers: Overview > MicroRNAs in cancer.
· Human Diseases > Cancers: Specific types > Gastric cancer. (View pathway)
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