AFfirm™ Histone H1 Mouse Monoclonal Antibody - #BF8983
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
H1 histone family member O oocyte specific; H1FOO; H1FOO_HUMAN; Histone H1oo; Oocyte-specific histone H1; Oocyte-specific linker histone H1; osH1;
免疫原
- Q8IZA3 H1FOO_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAPGSVTSDISPSSTSTAGSSRSPESEKPGPSHGGVPPGGPSHSSLPVGRRHPPVLRMVLEALQAGEQRRGTSVAAIKLYILHKYPTVDVLRFKYLLKQALATGMRRGLLARPLNSKARGATGSFKLVPKHKKKIQPRKMAPATAPRRAGEAKGKGPKKPSEAKEDPPNVGKVKKAAKRPAKVQKPPPKPGAATEKARKQGGAAKDTRAQSGEARKVPPKPDKAMRAPSSAGGLSRKAKAKGSRSSQGDAEAYRKTKAESKSSKPTASKVKNGAASPTKKKVVAKAKAPKAGQGPNTKAAAPAKGSGSKVVPAHLSRKTEAPKGPRKAGLPIKASSSKVSSQRAEA
PTMs - Q8IZA3 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T7 | Phosphorylation | Uniprot | |
| S26 | Phosphorylation | Uniprot | |
| R147 | Methylation | Uniprot | |
| K153 | Acetylation | Uniprot | |
| K155 | Acetylation | Uniprot | |
| K158 | Acetylation | Uniprot | |
| K205 | Methylation | Uniprot | |
| S245 | Phosphorylation | Uniprot | |
| S246 | Phosphorylation | Uniprot | |
| Y253 | Phosphorylation | Uniprot |
研究背景
May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling (By similarity).
Cytoplasm. Nucleus. Chromosome.
Oocyte-specific.
Belongs to the histone H1/H5 family.
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