AFfirm™ FAKD1 Mouse Monoclonal Antibody - #BF8993
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
FAKD1_HUMAN; FAST kinase domain containing protein 1; FAST kinase domain-containing protein 1; FAST kinase domains 1; FASTKD1; FLJ21901; KIAA1800; OTTHUMP00000207008; OTTHUMP00000207010;
免疫原
Expression detected in spleen, thymus, testis, ovary, colon, heart, smooth muscle, kidney, brain, lung, liver and white adipose tissue with highest expression in heart.
- Q53R41 FAKD1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MKKTPVFLESLVTNMLRLRAICPFSWRVFQFRPISCEPLIIQMNKCTDEEQMFGFIERNKAILSEKQVGCAFDMLWKLQKQKTSLLKNAEYVRDHPQFLTLHNLATNKFKLMNDDTLVNVLYVTQQFAGEAHDPLVEALVTEAWRRLERFDIKLLSEFSSCLADQHLYFSPLMGKIADIVHRNLETTQDLSSLSVLMVNISSLISRHFQQQLVNKTELLFDTIDSSEVNVAKSIAKFLRNVRYRYQPLLERCNNVFLSNVDHLDLDSISKILSVYKFLQFNSFEFIIMAKKKLTEMIPLCNHPASFVKLFVALGPIAGPEEKKQLKSTMLLMSEDLTGEQALAVLGAMGDMESRNSCLIKRVTSVLHKHLDGYKPLELLKITQELTFLHFQRKEFFAKLRELLLSYLKNSFIPTEVSVLVRAISLLPSPHLDEVGISRIEAVLPQCDLNNLSSFATSVLRWIQHDHMYLDNMTAKQLKLLQKLDHYGRQRLQHSNSLDLLRKELKSLKGNTFPESLLEEMIATLQHFMDDINYINVGEIASFISSTDYLSTLLLDRIASVAVQQIEKIHPFTIPAIIRPFSVLNYDPPQRDEFLGTCVQHLNSYLGILDPFILVFLGFSLATLEYFPEDLLKAIFNIKFLARLDSQLEILSPSRSARVQFHLMELNRSVCLECPEFQIPWFHDRFCQQYNKGIGGMDGTQQQIFKMLAEVLGGINCVKASVLTPYYHKVDFECILDKRKKPLPYGSHNIALGQLPEMPWESNIEIVGSRLPPGAERIALEFLDSKALCRNIPHMKGKSAMKKRHLEILGYRVIQISQFEWNSMALSTKDARMDYLRECIFGEVKSCL
PTMs - Q53R41 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K60 | Ubiquitination | Uniprot | |
| T83 | Phosphorylation | Uniprot | |
| K87 | Ubiquitination | Uniprot | |
| Y122 | Phosphorylation | Uniprot | |
| T124 | Phosphorylation | Uniprot | |
| Y168 | Phosphorylation | Uniprot | |
| S170 | Phosphorylation | Uniprot | |
| S194 | Phosphorylation | Uniprot | |
| S202 | Phosphorylation | Uniprot | |
| S305 | Phosphorylation | Uniprot | |
| K360 | Acetylation | Uniprot | |
| K374 | Ubiquitination | Uniprot | |
| S405 | Phosphorylation | Uniprot | |
| Y406 | Phosphorylation | Uniprot | |
| K478 | Ubiquitination | Uniprot | |
| K482 | Ubiquitination | Uniprot | |
| Y486 | Phosphorylation | Uniprot | |
| S496 | Phosphorylation | Uniprot | |
| T546 | Phosphorylation | Uniprot | |
| T551 | Phosphorylation | Uniprot | |
| K691 | Ubiquitination | Uniprot | |
| Y726 | Phosphorylation | Uniprot | |
| K728 | Ubiquitination | Uniprot | |
| K737 | Ubiquitination | Uniprot | |
| K785 | Ubiquitination | Uniprot | |
| Y810 | Phosphorylation | Uniprot | |
| K844 | Ubiquitination | Uniprot |
研究背景
Involved in the down-regulation of mitochondrial MT-ND3 mRNA levels which leads to decreased respiratory complex I abundance and activity.
Mitochondrion.
Note: Preferentially localizes to mitochondrial RNA granules, platforms for post-transcriptional RNA modification and ribosome assembly (PubMed:28335001).
Expression detected in spleen, thymus, testis, ovary, colon, heart, smooth muscle, kidney, brain, lung, liver and white adipose tissue with highest expression in heart.
The RAP domain is essential to regulate MT-ND3 mRNA levels.
Belongs to the FAST kinase family.
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.