AFfirm™ EGR2 Mouse Monoclonal Antibody - #BF9313
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
AT225; AT591; CMT1D; CMT4E; E3 SUMO-protein ligase EGR2; Early growth response 1; Early growth response 2; Early growth response protein 1; Early growth response protein 2; EGR1; EGR2; G0S30; KROX-24; KROX20; Nerve growth factor-induced protein A; NGFI A; NGFI-A; TIS8; Transcription factor ETR103; Transcription factor Zif268; ZIF-268; Zinc finger protein 225; Zinc finger protein Krox-20; Zinc finger protein Krox-24; ZNF225;
免疫原
- P11161 EGR2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MMTAKAVDKIPVTLSGFVHQLSDNIYPVEDLAATSVTIFPNAELGGPFDQMNGVAGDGMINIDMTGEKRSLDLPYPSSFAPVSAPRNQTFTYMGKFSIDPQYPGASCYPEGIINIVSAGILQGVTSPASTTASSSVTSASPNPLATGPLGVCTMSQTQPDLDHLYSPPPPPPPYSGCAGDLYQDPSAFLSAATTSTSSSLAYPPPPSYPSPKPATDPGLFPMIPDYPGFFPSQCQRDLHGTAGPDRKPFPCPLDTLRVPPPLTPLSTIRNFTLGGPSAGVTGPGASGGSEGPRLPGSSSAAAAAAAAAAYNPHHLPLRPILRPRKYPNRPSKTPVHERPYPCPAEGCDRRFSRSDELTRHIRIHTGHKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDYCGRKFARSDERKRHTKIHLRQKERKSSAPSASVPAPSTASCSGGVQPGGTLCSSNSSSLGGGPLAPCSSRTRTP
PTMs - P11161 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S70 | Phosphorylation | Uniprot | |
| Y75 | Phosphorylation | Uniprot | |
| S77 | Phosphorylation | Uniprot | |
| R257 | Methylation | Uniprot | |
| T263 | Phosphorylation | Uniprot | |
| R293 | Methylation | Uniprot | |
| T391 | Phosphorylation | Uniprot | |
| T393 | Phosphorylation | Uniprot |
研究背景
Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4.
E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 own transcriptional activity.
Ubiquitinated by WWP2 leading to proteasomal degradation.
Nucleus.
Interacts with HCFC1. Interacts with WWP2. Interacts with UBC9.
Belongs to the EGR C2H2-type zinc-finger protein family.
研究領域
· Human Diseases > Infectious diseases: Viral > Hepatitis B.
· Human Diseases > Infectious diseases: Viral > HTLV-I infection.
· Human Diseases > Cancers: Overview > Viral carcinogenesis.
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