AFfirm™ PDLIM1 Mouse Monoclonal Antibody - #BF9331
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
C terminal LIM domain protein 1; C-terminal LIM domain protein 1; Carboxy terminal LIM domain protein 1; CLIM 1; CLIM1; CLP 36; CLP36; Elfin; Enigma; Enigma homolog; hCLIM 1; hCLIM1; LIM domain protein CLP 36; LIM domain protein CLP-36; LIM domain protein CLP36; PDLI1_HUMAN; PDLIM 1; Pdlim1; PDZ and LIM domain 1; PDZ and LIM domain protein 1;
免疫原
Strongly expressed in the heart and skeletal muscle, moderately expressed in the spleen, small intestine, colon, placenta, and lung. A lower level expression is seen in liver, thymus, kidney, prostate and pancreas and is not found in the brain, testis, ovary, and peripheral blood leukocytes.
- O00151 PDLI1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTTQQIDLQGPGPWGFRLVGGKDFEQPLAISRVTPGSKAALANLCIGDVITAIDGENTSNMTHLEAQNRIKGCTDNLTLTVARSEHKVWSPLVTEEGKRHPYKMNLASEPQEVLHIGSAHNRSAMPFTASPASSTTARVITNQYNNPAGLYSSENISNFNNALESKTAASGVEANSRPLDHAQPPSSLVIDKESEVYKMLQEKQELNEPPKQSTSFLVLQEILESEEKGDPNKPSGFRSVKAPVTKVAASIGNAQKLPMCDKCGTGIVGVFVKLRDRHRHPECYVCTDCGTNLKQKGHFFVEDQIYCEKHARERVTPPEGYEVVTVFPK
PTMs - O00151 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T2 | Acetylation | Uniprot | |
| K22 | Acetylation | Uniprot | |
| K22 | Ubiquitination | Uniprot | |
| S31 | Phosphorylation | Uniprot | |
| T34 | Phosphorylation | Uniprot | |
| K71 | Ubiquitination | Uniprot | |
| C73 | S-Nitrosylation | Uniprot | |
| K87 | Methylation | Uniprot | |
| K87 | Ubiquitination | Uniprot | |
| S90 | Phosphorylation | Uniprot | |
| T94 | O-Glycosylation | Uniprot | |
| K98 | Acetylation | Uniprot | |
| K98 | Ubiquitination | Uniprot | |
| S108 | Phosphorylation | Uniprot | |
| S118 | Phosphorylation | Uniprot | |
| S123 | Phosphorylation | Uniprot | |
| T128 | Phosphorylation | Uniprot | |
| S130 | Phosphorylation | Uniprot | |
| S133 | Phosphorylation | Uniprot | |
| S134 | Phosphorylation | Uniprot | |
| T136 | Phosphorylation | Uniprot | |
| T141 | Phosphorylation | Uniprot | |
| Y144 | Phosphorylation | Uniprot | |
| Y151 | Phosphorylation | Uniprot | |
| S152 | Phosphorylation | Uniprot | |
| S153 | Phosphorylation | Uniprot | |
| S186 | Phosphorylation | Uniprot | |
| S187 | Phosphorylation | Uniprot | |
| K192 | Ubiquitination | Uniprot | |
| S194 | Phosphorylation | Uniprot | |
| Y197 | Phosphorylation | Uniprot | |
| K198 | Ubiquitination | Uniprot | |
| K203 | Ubiquitination | Uniprot | |
| K211 | Ubiquitination | Uniprot | |
| S213 | Phosphorylation | Uniprot | |
| T214 | Phosphorylation | Uniprot | |
| S215 | Phosphorylation | Uniprot | |
| K233 | Ubiquitination | Uniprot | |
| S235 | Phosphorylation | Uniprot | |
| S239 | Phosphorylation | Uniprot | |
| K241 | Ubiquitination | Uniprot | |
| K246 | Acetylation | Uniprot | |
| K246 | Ubiquitination | Uniprot | |
| S250 | Phosphorylation | Uniprot | |
| K256 | Ubiquitination | Uniprot | |
| T291 | Phosphorylation | Uniprot | |
| Y306 | Phosphorylation | Uniprot | |
| K309 | Ubiquitination | Uniprot | |
| T316 | Phosphorylation | Uniprot | |
| Y321 | Phosphorylation | Uniprot | |
| T325 | Phosphorylation | Uniprot |
研究背景
Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton. Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts (By similarity).
Cytoplasm. Cytoplasm>Cytoskeleton. Cytoplasm>Myofibril>Sarcomere>Z line.
Note: Associates with actin stress fibers.
Strongly expressed in the heart and skeletal muscle, moderately expressed in the spleen, small intestine, colon, placenta, and lung. A lower level expression is seen in liver, thymus, kidney, prostate and pancreas and is not found in the brain, testis, ovary, and peripheral blood leukocytes.
Interacts with ACTN1, ACTN2 and ACTN4. Interacts with PDLIM4 (By similarity).
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