AFfirm™ ILKAP Mouse Monoclonal Antibody - #BF9335
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
DKFZp434J2031; FLJ10181; ILKAP; ILKAP_HUMAN; ILKAP2; ILKAP3; Integrin linked kinase associated phosphatase; Integrin linked kinase associated serine/threonine phosphatase 2C; Integrin linked kinase associated serine/threonine phosphatase; Integrin-linked kinase-associated serine/threonine phosphatase 2C; MGC4846; PP2C DELTA; Protein phosphatase 2c delta isozyme;
免疫原
Widely expressed. Highest levels expressed in striated muscle. Much lower levels evident in various smooth muscle tissues.
- Q9H0C8 ILKAP_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDLFGDLPEPERSPRPAAGKEAQKGPLLFDDLPPASSTDSGSGGPLLFDDLPPASSGDSGSLATSISQMVKTEGKGAKRKTSEEEKNGSEELVEKKVCKASSVIFGLKGYVAERKGEREEMQDAHVILNDITEECRPPSSLITRVSYFAVFDGHGGIRASKFAAQNLHQNLIRKFPKGDVISVEKTVKRCLLDTFKHTDEEFLKQASSQKPAWKDGSTATCVLAVDNILYIANLGDSRAILCRYNEESQKHAALSLSKEHNPTQYEERMRIQKAGGNVRDGRVLGVLEVSRSIGDGQYKRCGVTSVPDIRRCQLTPNDRFILLACDGLFKVFTPEEAVNFILSCLEDEKIQTREGKSAADARYEAACNRLANKAVQRGSADNVTVMVVRIGH
PTMs - Q9H0C8 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| S13 | Phosphorylation | Uniprot | |
| T81 | Phosphorylation | Uniprot | |
| S82 | Phosphorylation | Uniprot | |
| K86 | Acetylation | Uniprot | |
| K95 | Acetylation | Uniprot | |
| K161 | Acetylation | Uniprot | |
| K161 | Ubiquitination | Uniprot | |
| K185 | Ubiquitination | Uniprot | |
| C190 | S-Nitrosylation | Uniprot | |
| K196 | Ubiquitination | Uniprot | |
| K204 | Methylation | Uniprot | |
| K204 | Ubiquitination | Uniprot | |
| K210 | Acetylation | Uniprot | |
| K210 | Ubiquitination | Uniprot | |
| K250 | Ubiquitination | Uniprot | |
| K258 | Ubiquitination | Uniprot | |
| T263 | Phosphorylation | Uniprot | |
| Y265 | Phosphorylation | Uniprot | |
| K273 | Ubiquitination | Uniprot | |
| S290 | Phosphorylation | Uniprot | |
| Y298 | Phosphorylation | Uniprot | |
| T304 | Phosphorylation | Uniprot | |
| S305 | Phosphorylation | Uniprot | |
| R319 | Methylation | Uniprot | |
| R369 | Methylation | Uniprot | |
| R377 | Methylation | Uniprot |
研究背景
Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation.
Cytoplasm.
Widely expressed. Highest levels expressed in striated muscle. Much lower levels evident in various smooth muscle tissues.
Interacts with ILK. Specific association with ILK is independent of the catalytic activity of either partner.
Belongs to the PP2C family.
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