AFfirm™ APPBP2 Mouse Monoclonal Antibody - #BF9346
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
amyloid beta precursor protein (cytoplasmic tail) binding protein 2; Amyloid beta precursor protein-binding protein 2; Amyloid protein binding protein 2; Amyloid protein-binding protein 2; APBP2_HUMAN; APP BP2; APP-BP2; Appbp2; PAT1; Protein interacting with APP tail 1;
免疫原
- Q92624 APBP2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAAVELEWIPETLYNTAISAVVDNYIRSRRDIRSLPENIQFDVYYKLYQQGRLCQLGSEFCELEVFAKVLRALDKRHLLHHCFQALMDHGVKVASVLAYSFSRRCSYIAESDAAVKEKAIQVGFVLGGFLSDAGWYSDAEKVFLSCLQLCTLHDEMLHWFRAVECCVRLLHVRNGNCKYHLGEETFKLAQTYMDKLSKHGQQANKAALYGELCALLFAKSHYDEAYKWCIEAMKEITAGLPVKVVVDVLRQASKACVVKREFKKAEQLIKHAVYLARDHFGSKHPKYSDTLLDYGFYLLNVDNICQSVAIYQAALDIRQSVFGGKNIHVATAHEDLAYSSYVHQYSSGKFDNALFHAERAIGIITHILPEDHLLLASSKRVKALILEEIAIDCHNKETEQRLLQEAHDLHLSSLQLAKKAFGEFNVQTAKHYGNLGRLYQSMRKFKEAEEMHIKAIQIKEQLLGQEDYEVALSVGHLASLYNYDMNQYENAEKLYLRSIAIGKKLFGEGYSGLEYDYRGLIKLYNSIGNYEKVFEYHNVLSNWNRLRDRQYSVTDALEDVSTSPQSTEEVVQSFLISQNVEGPSC
PTMs - Q92624 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K68 | Methylation | Uniprot | |
| K68 | Ubiquitination | Uniprot | |
| S106 | Phosphorylation | Uniprot | |
| K178 | Ubiquitination | Uniprot | |
| K187 | Ubiquitination | Uniprot | |
| K195 | Ubiquitination | Uniprot | |
| K198 | Ubiquitination | Uniprot | |
| T237 | Phosphorylation | Uniprot | |
| K254 | Ubiquitination | Uniprot | |
| K264 | Ubiquitination | Uniprot | |
| K283 | Ubiquitination | Uniprot | |
| K349 | Ubiquitination | Uniprot | |
| K379 | Ubiquitination | Uniprot | |
| K396 | Ubiquitination | Uniprot | |
| K418 | Ubiquitination | Uniprot | |
| K419 | Ubiquitination | Uniprot | |
| K430 | Ubiquitination | Uniprot | |
| K446 | Ubiquitination | Uniprot | |
| K454 | Ubiquitination | Uniprot | |
| K504 | Ubiquitination | Uniprot | |
| Y517 | Phosphorylation | Uniprot | |
| K522 | Ubiquitination | Uniprot |
研究背景
May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface.
Rapidly degraded by the proteasome upon overexpression of a C-terminal fragment of APP.
Nucleus. Cytoplasm>Cytoskeleton. Membrane>Peripheral membrane protein.
Note: Associated with membranes and microtubules.
Binds APP.
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