AFfirm™ NAMPT Mouse Monoclonal Antibody - #BF9373
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
1110035O14Rik; AI314458; AI480535; DKFZP666B131; EC 2.4.2.12; MGC117256; NAmPRTase; Nampt; NAMPT_HUMAN; Nicotinamide phosphoribosyltransferase; PBEF 1; PBEF; PBEF1; Pre B cell colony enhancing factor 1; Pre B cell colony enhancing factor; Pre B cell enhancing factor; Pre-B cell-enhancing factor; Pre-B-cell colony-enhancing factor 1; VF; Visfatin;
免疫原
Expressed in large amounts in bone marrow, liver tissue, and muscle. Also present in heart, placenta, lung, and kidney tissues.
- P43490 NAMPT_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH
PTMs - P43490 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| T15 | Phosphorylation | Uniprot | |
| S17 | Phosphorylation | Uniprot | |
| Y18 | Phosphorylation | Uniprot | |
| K24 | Ubiquitination | Uniprot | |
| Y26 | Phosphorylation | Uniprot | |
| Y34 | Phosphorylation | Uniprot | |
| Y36 | Phosphorylation | Uniprot | |
| K48 | Ubiquitination | Uniprot | |
| Y54 | Phosphorylation | Uniprot | |
| T57 | Phosphorylation | Uniprot | |
| Y60 | Phosphorylation | Uniprot | |
| Y64 | Phosphorylation | Uniprot | |
| Y69 | Phosphorylation | Uniprot | |
| K84 | Ubiquitination | Uniprot | |
| Y87 | Phosphorylation | Uniprot | |
| K88 | Ubiquitination | Uniprot | |
| K99 | Ubiquitination | Uniprot | |
| K107 | Ubiquitination | Uniprot | |
| K117 | Ubiquitination | Uniprot | |
| K174 | Ubiquitination | Uniprot | |
| Y175 | Phosphorylation | Uniprot | |
| Y188 | Phosphorylation | Uniprot | |
| K189 | Ubiquitination | Uniprot | |
| R196 | Methylation | Uniprot | |
| K228 | Ubiquitination | Uniprot | |
| K229 | Ubiquitination | Uniprot | |
| K234 | Ubiquitination | Uniprot | |
| S241 | Phosphorylation | Uniprot | |
| K255 | Ubiquitination | Uniprot | |
| K259 | Ubiquitination | Uniprot | |
| S314 | Phosphorylation | Uniprot | |
| K330 | Ubiquitination | Uniprot | |
| K331 | Ubiquitination | Uniprot | |
| T335 | Phosphorylation | Uniprot | |
| S338 | Phosphorylation | Uniprot | |
| K339 | Ubiquitination | Uniprot | |
| K342 | Ubiquitination | Uniprot | |
| K369 | Acetylation | Uniprot | |
| K369 | Ubiquitination | Uniprot | |
| K371 | Ubiquitination | Uniprot | |
| S374 | Phosphorylation | Uniprot | |
| S382 | Phosphorylation | Uniprot | |
| K389 | Ubiquitination | Uniprot | |
| S398 | Phosphorylation | Uniprot | |
| Y403 | Phosphorylation | Uniprot | |
| K415 | Acetylation | Uniprot | |
| K423 | Acetylation | Uniprot | |
| K423 | Ubiquitination | Uniprot | |
| S431 | Phosphorylation | Uniprot | |
| T435 | Phosphorylation | Uniprot | |
| K447 | Ubiquitination | Uniprot | |
| Y453 | Phosphorylation | Uniprot | |
| K469 | Ubiquitination | Uniprot | |
| S470 | Phosphorylation | Uniprot | |
| S472 | Phosphorylation | Uniprot |
研究背景
Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity).
Nucleus. Cytoplasm. Secreted.
Note: Under non-inflammatory conditions, visfatin predominantly exhibits a granular pattern within the nucleus. Secreted by endothelial cells upon IL-1beta stimulation. Abundantly secreted in milk, reaching 100-fold higher concentrations compared to maternal serum.
Expressed in large amounts in bone marrow, liver tissue, and muscle. Also present in heart, placenta, lung, and kidney tissues.
Homodimer.
Belongs to the NAPRTase family.
研究領域
· Metabolism > Metabolism of cofactors and vitamins > Nicotinate and nicotinamide metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
· Organismal Systems > Immune system > NOD-like receptor signaling pathway. (View pathway)
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