FRK Antibody - #DF3179
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF3179, RRID:AB_2835402.
折りたたみ／展開
Beta cell Src homology tyrosine kinase; BSK; BSK/IYK; C85044; Frk; Frk fyn related kinase; FRK_HUMAN; FYN related kinase; FYN-related kinase; GASK; Gastrointestinal associated kinase; Gastrointestinal associated tyrosine kinase; GTK; GTK, mouse, homolog of; Intestine tyrosine kinase; Nuclear tyrosine protein kinase RAK; Protein-tyrosine kinase 5; PTK5; PTK5 protein tyrosine kinase 5; RAK; Tyrosine protein kinase FRK; Tyrosine-protein kinase FRK;
免疫原
Predominantly expressed in epithelial derived cell lines and tissues, especially normal liver, kidney, breast and colon.
- P42685 FRK_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSNICQRLWEYLEPYLPCLSTEADKSTVIENPGALCSPQSQRHGHYFVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVAEDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTFETLRWKLEDYFETDSSYSDANNFIR
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P42685 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S37 | Phosphorylation | Uniprot | |
| S40 | Phosphorylation | Uniprot | |
| Y46 | Phosphorylation | Uniprot | |
| Y53 | Phosphorylation | Uniprot | |
| T57 | Phosphorylation | Uniprot | |
| S62 | Phosphorylation | Uniprot | |
| S92 | Phosphorylation | Uniprot | |
| S93 | Phosphorylation | Uniprot | |
| Y99 | Phosphorylation | Uniprot | |
| S102 | Phosphorylation | Uniprot | |
| Y104 | Phosphorylation | Uniprot | |
| Y132 | Phosphorylation | Uniprot | |
| S133 | Phosphorylation | Uniprot | |
| S139 | Phosphorylation | Uniprot | |
| T178 | Phosphorylation | Uniprot | |
| S184 | Phosphorylation | Uniprot | |
| Y193 | Phosphorylation | Uniprot | |
| Y221 | Phosphorylation | Uniprot | |
| S233 | Phosphorylation | Uniprot | |
| Y303 | Phosphorylation | Uniprot | |
| Y317 | Phosphorylation | Uniprot | |
| Y368 | Phosphorylation | Uniprot | |
| Y387 | Phosphorylation | P42685 (FRK) | Uniprot |
| S389 | Phosphorylation | Uniprot | |
| S407 | Phosphorylation | Uniprot | |
| K409 | Acetylation | Uniprot | |
| S495 | Phosphorylation | Uniprot | |
| S496 | Phosphorylation | Uniprot | |
| Y497 | Phosphorylation | P41240 (CSK) | Uniprot |
| S498 | Phosphorylation | Uniprot |
PTMs - P42685 酵素として
研究背景
Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.
Cytoplasm. Nucleus.
Note: Predominantly found in the nucleus, with a small fraction found in the cell periphery.
Predominantly expressed in epithelial derived cell lines and tissues, especially normal liver, kidney, breast and colon.
Interacts (via the SH3-domain) with PTEN. Interacts with RB1.
Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
Restrictive clause
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For Research Use Only.
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