AFfirm™ PPP1R14B Mouse Monoclonal Antibody - #BF9413
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
PHI 1; PHI1; Phospholipase C beta 3 neighboring gene protein; Phospholipase C beta 3 neighbouring gene protein; Phospholipase C-beta-3 neighbouring gene protein; PLCB3N; PNG; PP14B_HUMAN; Ppp1r14b; Protein phosphatase 1 regulatory (inhibitor) subunit 14B; Protein phosphatase 1 regulatory subunit 14B; SOM172;
免疫原
- Q96C90 PP14B_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MADSGTAGGAALAAPAPGPGSGGPGPRVYFQSPPGAAGEGPGGADDEGPVRRQGKVTVKYDRKELRKRLNLEEWILEQLTRLYDCQEEEIPELEIDVDELLDMESDDARAARVKELLVDCYKPTEAFISGLLDKIRGMQKLSTPQKK
PTMs - Q96C90 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| S4 | Phosphorylation | Uniprot | |
| S21 | Phosphorylation | Uniprot | |
| R27 | Methylation | Uniprot | |
| Y29 | Phosphorylation | Uniprot | |
| S32 | Phosphorylation | Uniprot | |
| T57 | Phosphorylation | O75116 (ROCK2) , P17252 (PRKCA) , Q05655 (PRKCD) , Q13418 (ILK) | Uniprot |
| K59 | Acetylation | Uniprot | |
| K59 | Methylation | Uniprot | |
| K114 | Ubiquitination | Uniprot | |
| Y121 | Phosphorylation | Uniprot | |
| K122 | Ubiquitination | Uniprot | |
| S142 | Phosphorylation | Uniprot | |
| T143 | Phosphorylation | Uniprot |
研究背景
Inhibitor of PPP1CA. Has over 50-fold higher inhibitory activity when phosphorylated (By similarity).
Phosphorylated primarily on Thr-57 by PKC (in vitro). An unknown Ser is also phosphorylated by PKC (in vitro) (By similarity).
Cytoplasm.
Ubiquitous. Expressed at low levels.
Belongs to the PP1 inhibitor family.
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