AFfirm™ ADAM23 Mouse Monoclonal Antibody - #BF9416
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
A disintegrin and metalloproteinase domain 23; ADAM metallopeptidase domain 23; Disintegrin and metalloproteinase domain containing protein 23; MDC 3; MDC3; Metalloproteinase like disintegrin like and cysteine rich protein 3;
免疫原
Highly expressed in the brain and weakly expressed in the heart. In the brain, expressed prominently in the amygdala, caudate nucleus, hypothalamus, thalamus, cerebral cortex and occipital pole.
- O75077 ADA23_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MKPPGSSSRQPPLAGCSLAGASCGPQRGPAGSVPASAPARTPPCRLLLVLLLLPPLAASSRPRAWGAAAPSAPHWNETAEKNLGVLADEDNTLQQNSSSNISYSNAMQKEITLPSRLIYYINQDSESPYHVLDTKARHQQKHNKAVHLAQASFQIEAFGSKFILDLILNNGLLSSDYVEIHYENGKPQYSKGGEHCYYHGSIRGVKDSKVALSTCNGLHGMFEDDTFVYMIEPLELVHDEKSTGRPHIIQKTLAGQYSKQMKNLTMERGDQWPFLSELQWLKRRKRAVNPSRGIFEEMKYLELMIVNDHKTYKKHRSSHAHTNNFAKSVVNLVDSIYKEQLNTRVVLVAVETWTEKDQIDITTNPVQMLHEFSKYRQRIKQHADAVHLISRVTFHYKRSSLSYFGGVCSRTRGVGVNEYGLPMAVAQVLSQSLAQNLGIQWEPSSRKPKCDCTESWGGCIMEETGVSHSRKFSKCSILEYRDFLQRGGGACLFNRPTKLFEPTECGNGYVEAGEECDCGFHVECYGLCCKKCSLSNGAHCSDGPCCNNTSCLFQPRGYECRDAVNECDITEYCTGDSGQCPPNLHKQDGYACNQNQGRCYNGECKTRDNQCQYIWGTKAAGSDKFCYEKLNTEGTEKGNCGKDGDRWIQCSKHDVFCGFLLCTNLTRAPRIGQLQGEIIPTSFYHQGRVIDCSGAHVVLDDDTDVGYVEDGTPCGPSMMCLDRKCLQIQALNMSSCPLDSKGKVCSGHGVCSNEATCICDFTWAGTDCSIRDPVRNLHPPKDEGPKGPSATNLIIGSIAGAILVAAIVLGGTGWGFKNVKKRRFDPTQQGPI
PTMs - O75077 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y119 | Phosphorylation | Uniprot | |
| S127 | Phosphorylation | Uniprot | |
| Y129 | Phosphorylation | Uniprot | |
| T265 | Phosphorylation | Uniprot | |
| T352 | Phosphorylation | Uniprot | |
| T354 | Phosphorylation | Uniprot | |
| T393 | Phosphorylation | Uniprot | |
| Y396 | Phosphorylation | Uniprot | |
| Y403 | Phosphorylation | Uniprot | |
| T453 | Phosphorylation | Uniprot | |
| S473 | Phosphorylation | Uniprot | |
| Y707 | Phosphorylation | Uniprot |
研究背景
May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein.
Cell membrane>Single-pass type I membrane protein.
Secreted.
Highly expressed in the brain and weakly expressed in the heart. In the brain, expressed prominently in the amygdala, caudate nucleus, hypothalamus, thalamus, cerebral cortex and occipital pole.
Can bind to LGI1 and LGI4 (By similarity). Ligand for integrin alpha-V/beta-3.
A conserved motif AVN[ED]CD within the disintegrin-like domain could be involved in the binding to the integrin receptor.
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