AFfirm™ SRR Mouse Monoclonal Antibody - #BF9417
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
D serine ammonia lyase; D serine dehydratase; D-serine ammonia-lyase; D-serine dehydratase; ILV1; ISO1; L serine ammonia lyase; L serine dehydratase; L-serine ammonia-lyase; L-serine dehydratase; Serine racemase; srr; SRR_HUMAN;
免疫原
Brain: expressed at high levels in hippocampus and corpus callosum, intermediate levels in substantia nigra and caudate, and low levels in amygdala, thalamus, and subthalamic nuclei. Expressed in heart, skeletal muscle, kidney and liver.
- Q9GZT4 SRR_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MCAQYCISFADVEKAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDALERKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCEPSDESRENVAKRVTEETEGIMVHPNQEPAVIAGQGTIALEVLNQVPLVDALVVPVGGGGMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKSSIGLNTWPIIRDLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQTVSPEVKNICIVLSGGNVDLTSSITWVKQAERPASYQSVSV
PTMs - Q9GZT4 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K45 | Ubiquitination | Uniprot | |
| K51 | Ubiquitination | Uniprot | |
| K56 | Methylation | Uniprot | |
| K56 | Ubiquitination | Uniprot | |
| C113 | S-Nitrosylation | Uniprot | |
| S134 | Phosphorylation | Uniprot | |
| K205 | Ubiquitination | Uniprot | |
| Y207 | Phosphorylation | Uniprot | |
| S212 | Phosphorylation | Uniprot | |
| C217 | S-Nitrosylation | Uniprot | |
| Y218 | Phosphorylation | Uniprot | |
| S220 | Phosphorylation | Uniprot | |
| K221 | Ubiquitination | Uniprot | |
| K225 | Ubiquitination | Uniprot | |
| S242 | Phosphorylation | Uniprot | |
| S339 | Phosphorylation | Uniprot |
研究背景
Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine.
S-nitrosylated, leading to decrease the enzyme activity.
Brain: expressed at high levels in hippocampus and corpus callosum, intermediate levels in substantia nigra and caudate, and low levels in amygdala, thalamus, and subthalamic nuclei. Expressed in heart, skeletal muscle, kidney and liver.
Homodimer.
Belongs to the serine/threonine dehydratase family.
研究領域
· Metabolism > Amino acid metabolism > Glycine, serine and threonine metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
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