AFfirm™ ACP5 Mouse Monoclonal Antibody - #BF9425
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
Type 5 acid phosphatase; Acid phosphatase 5 tartrate resistant; Acid phosphatase 5, tartrate resistant; ACP5; EC 3.1.3.2; MGC117378; PPA5_HUMAN; serum band 5 tartrate-resistant acid phosphatase; SPENCDI; T5ap; Tartrate resistant acid ATPase; Tartrate resistant acid phosphatase type 5; Tartrate resistant acid phosphatase type 5 precursor; Tartrate-resistant acid ATPase; Tartrate-resistant acid phosphatase type 5; TR AP; TR-AP; TRACP 5; TRAP; TrATPase; Type 5 acid phosphatase;
免疫原
- P13686 PPA5_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDMWTALLILQALLLPSLADGATPALRFVAVGDWGGVPNAPFHTAREMANAKEIARTVQILGADFILSLGDNFYFTGVQDINDKRFQETFEDVFSDRSLRKVPWYVLAGNHDHLGNVSAQIAYSKISKRWNFPSPFYRLHFKIPQTNVSVAIFMLDTVTLCGNSDDFLSQQPERPRDVKLARTQLSWLKKQLAAAREDYVLVAGHYPVWSIAEHGPTHCLVKQLRPLLATYGVTAYLCGHDHNLQYLQDENGVGYVLSGAGNFMDPSKRHQRKVPNGYLRFHYGTEDSLGGFAYVEISSKEMTVTYIEASGKSLFKTRLPRRARP
PTMs - P13686 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| N116 | N-Glycosylation | Uniprot | |
| K222 | Ubiquitination | Uniprot | |
| Y278 | Phosphorylation | Uniprot | |
| Y283 | Phosphorylation | Uniprot |
研究背景
Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias.
Lysosome.
Exists either as monomer or, after proteolytic processing, as a dimer of two chains linked by disulfide bond(s).
Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.
研究領域
· Cellular Processes > Transport and catabolism > Lysosome. (View pathway)
· Human Diseases > Immune diseases > Rheumatoid arthritis.
· Metabolism > Metabolism of cofactors and vitamins > Riboflavin metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
· Organismal Systems > Development > Osteoclast differentiation. (View pathway)
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