AFfirm™ SMG9 Mouse Monoclonal Antibody - #BF9429
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
Chromosome 19 open reading frame 61; DKFZp564H1322; F17127_1; FLJ12886; Protein smg 9 homolog; Protein smg-9 homolog; Protein SMG9; SMG 9; smg9; SMG9_HUMAN; Suppressor with morphogenetic effect on genitalia protein 9,;
免疫原
- Q9H0W8 SMG9_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSESGHSQPGLYGIERRRRWKEPGSGGPQNLSGPGGRERDYIAPWERERRDASEETSTSVMQKTPIILSKPPAERSKQPPPPTAPAAPPAPAPLEKPIVLMKPREEGKGPVAVTGASTPEGTAPPPPAAPAPPKGEKEGQRPTQPVYQIQNRGMGTAAPAAMDPVVGQAKLLPPERMKHSIKLVDDQMNWCDSAIEYLLDQTDVLVVGVLGLQGTGKSMVMSLLSANTPEEDQRTYVFRAQSAEMKERGGNQTSGIDFFITQERIVFLDTQPILSPSILDHLINNDRKLPPEYNLPHTYVEMQSLQIAAFLFTVCHVVIVVQDWFTDLSLYRFLQTAEMVKPSTPSPSHESSSSSGSDEGTEYYPHLVFLQNKARREDFCPRKLRQMHLMIDQLMAHSHLRYKGTLSMLQCNVFPGLPPDFLDSEVNLFLVPFMDSEAESENPPRAGPGSSPLFSLLPGYRGHPSFQSLVSKLRSQVMSMARPQLSHTILTEKNWFHYAARIWDGVRKSSALAEYSRLLA
PTMs - Q9H0W8 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Acetylation | Uniprot | |
| S2 | Phosphorylation | Uniprot | |
| S4 | Phosphorylation | Uniprot | |
| S7 | Phosphorylation | Uniprot | |
| Y12 | Phosphorylation | Uniprot | |
| K21 | Methylation | Uniprot | |
| S25 | Phosphorylation | Uniprot | |
| S32 | Phosphorylation | Uniprot | |
| Y41 | Phosphorylation | Uniprot | |
| S53 | Phosphorylation | Uniprot | |
| T64 | Phosphorylation | Uniprot | |
| S69 | Phosphorylation | Uniprot | |
| T114 | Phosphorylation | Uniprot | |
| S117 | Phosphorylation | Uniprot | |
| T118 | Phosphorylation | Uniprot | |
| T122 | Phosphorylation | Uniprot | |
| K137 | Ubiquitination | Uniprot | |
| T143 | Phosphorylation | Uniprot | |
| Y147 | Phosphorylation | Uniprot | |
| K170 | Ubiquitination | Uniprot | |
| R248 | Methylation | Uniprot | |
| K373 | Ubiquitination | Uniprot | |
| S451 | Phosphorylation | Uniprot | |
| K472 | Ubiquitination | Uniprot | |
| K508 | Ubiquitination | Uniprot |
研究背景
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between SMG1 and SMG8. Plays a role in brain, heart, and eye development (By similarity).
Phosphorylated by SMG1.
Component of the SMG1C complex composed of SMG1, SMG8 and SMG9. Self-associates to form homodimers and forms heterodimers with SMG8; these assembly forms may represent SMG1C intermediate forms.
Belongs to the SMG9 family.
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