CLK1 Antibody - #DF3189
| 製品: | CLK1 Antibody |
| カタログ: | DF3189 |
| タンパク質の説明: | Rabbit polyclonal antibody to CLK1 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse |
| 予測: | Rabbit, Dog |
| 分子量: | 57 KD; 57kD(Calculated). |
| ユニプロット: | P49759 |
| RRID: | AB_2835412 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF3189, RRID:AB_2835412.
折りたたみ／展開
CDC like kinase 1; CDC-like kinase 1; CDC28/CDC2 like kinase; CLK; CLK/STY; Clk1; CLK1_HUMAN; Dual specificity protein kinase CLK1; Protein tyrosine kinase STY; STY;
免疫原
- P49759 CLK1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P49759 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K15 | Ubiquitination | Uniprot | |
| K21 | Sumoylation | Uniprot | |
| K21 | Ubiquitination | Uniprot | |
| S24 | Phosphorylation | Uniprot | |
| S34 | Phosphorylation | Uniprot | |
| S36 | Phosphorylation | Uniprot | |
| S37 | Phosphorylation | Uniprot | |
| K50 | Sumoylation | Uniprot | |
| K50 | Ubiquitination | Uniprot | |
| S54 | Phosphorylation | Uniprot | |
| Y56 | Phosphorylation | Uniprot | |
| S59 | Phosphorylation | Uniprot | |
| S61 | Phosphorylation | Uniprot | |
| K65 | Ubiquitination | Uniprot | |
| Y76 | Phosphorylation | Uniprot | |
| Y80 | Phosphorylation | Uniprot | |
| S101 | Phosphorylation | Uniprot | |
| S102 | Phosphorylation | Uniprot | |
| S104 | Phosphorylation | Uniprot | |
| S122 | Phosphorylation | Uniprot | |
| T123 | Phosphorylation | Uniprot | |
| T138 | Phosphorylation | Uniprot | |
| S140 | Phosphorylation | Uniprot | |
| S158 | Phosphorylation | Uniprot | |
| K174 | Ubiquitination | Uniprot | |
| K182 | Ubiquitination | Uniprot | |
| K191 | Sumoylation | Uniprot | |
| K191 | Ubiquitination | Uniprot | |
| T285 | Phosphorylation | Uniprot | |
| K290 | Ubiquitination | Uniprot | |
| S299 | Phosphorylation | Uniprot | |
| Y305 | Phosphorylation | Uniprot | |
| K308 | Ubiquitination | Uniprot | |
| K322 | Sumoylation | Uniprot | |
| S328 | Phosphorylation | Uniprot | |
| T330 | Phosphorylation | Uniprot | |
| S337 | Phosphorylation | Uniprot | |
| T338 | Phosphorylation | Uniprot | |
| S341 | Phosphorylation | Uniprot | |
| T342 | Phosphorylation | Uniprot | |
| Y345 | Phosphorylation | Uniprot | |
| K400 | Ubiquitination | Uniprot | |
| K464 | Ubiquitination | Uniprot | |
| K481 | Ubiquitination | Uniprot |
PTMs - P49759 酵素として
| Substrate | Site | Source |
|---|---|---|
| P00519 (ABL1) | T735 | Uniprot |
| P18031 (PTPN1) | S50 | Uniprot |
| P18031 (PTPN1) | S242 | Uniprot |
| P18031 (PTPN1) | S243 | Uniprot |
| Q96I25 (RBM17) | S48 | Uniprot |
| Q96I25 (RBM17) | S62 | Uniprot |
| Q96I25 (RBM17) | S202 | Uniprot |
| Q96I25 (RBM17) | S204 | Uniprot |
| Q96I25 (RBM17) | S222 | Uniprot |
| Q96I25 (RBM17) | S266 | Uniprot |
| Q96I25 (RBM17) | S288 | Uniprot |
| Q96I25 (RBM17) | S291 | Uniprot |
研究背景
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA.
Autophosphorylates on all three types of residues.
Nucleus.
Endothelial cells.
Interacts with PPIG and UBL5.
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.
研究領域
· Human Diseases > Infectious diseases: Bacterial > Legionellosis.
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