AFfirm™ SDPR Mouse Monoclonal Antibody - #BF9531

製品: SDPR Mouse Monoclonal Antibody
カタログ: BF9531
タンパク質の説明: Mouse monoclonal antibody to SDPR
アプリケーション: WB
反応性: Human
予測: Mouse, Rat, Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
分子量: 70 kDa; 47kD(Calculated).
ユニプロット: O95810

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MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Mouse
アプリケーション:
WB 1:500-1:3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human
クローナリティ:
Monoclonal [AFfirm9531]
特異性:
SDPR Mouse Monoclonal Antibody detects endogenous levels of total SDPR.
コンジュゲート:
Unconjugated.
精製:
Affinity-chromatography.
保存:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

Cavin 2; Cavin-2; Phosphatidylserine binding protein; Phosphatidylserine-binding protein; PS p68; PS-p68; Sdpr; SDPR_HUMAN; SDR; Serum deprivation response; Serum deprivation response protein; Serum deprivation-response protein;

免疫原

免疫原:

A synthesized peptide derived from human SDPR, corresponding to a region within the internal amino acids.

Uniprot:

O95810(CAVN2_HUMAN) >>Visit HPA database.

遺伝子(ID):
CAVIN2(8436)
発現特異性:
O95810 CAVN2_HUMAN:

Highly expressed in heart and lung, and expressed at lower levels in brain, kidney, liver, pancreas, placenta, and skeletal muscle.

タンパク質配列:
MGEDAAQAEKFQHPGSDMRQEKPSSPSPMPSSTPSPSLNLGNTEEAIRDNSQVNAVTVLTLLDKLVNMLDAVQENQHKMEQRQISLEGSVKGIQNDLTKLSKYQASTSNTVSKLLEKSRKVSAHTRAVKERMDRQCAQVKRLENNHAQLLRRNHFKVLIFQEENEIPASVFVKQPVSGAVEGKEELPDENKSLEETLHTVDLSSDDDLPHDEEALEDSAEEKVEESRAEKIKRSSLKKVDSLKKAFSRQNIEKKMNKLGTKIVSVERREKIKKSLTSNHQKISSGKSSPFKVSPLTFGRKKVREGESHAENETKSEDLPSSEQMPNDQEEESFAEGHSEASLASALVEGEIAEEAAEKATSRGSNSGMDSNIDLTIVEDEEEESVALEQAQKVRYEGSYALTSEEAERSDGDPVQPAVLQVHQTS

研究背景

機能:

Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae. Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells. May play a role in targeting PRKCA to caveolae (By similarity).

PTMs:

Phosphorylated on Ser residues.

細胞の位置付け:

Cytoplasm>Cytosol. Membrane>Caveola.
Note: Localizes in the caveolae in a caveolin-dependent manner.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Highly expressed in heart and lung, and expressed at lower levels in brain, kidney, liver, pancreas, placenta, and skeletal muscle.

タンパク質ファミリー:

The leucine-zipper domain is essential for its localization in the caveolae.

Belongs to the CAVIN family.

Restrictive clause

 

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