MEOX2 Antibody - #DF3192
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製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF3192, RRID:AB_2835415.
折りたたみ／展開
GAX; Growth arrest-specific homeobox; Homeobox protein MOX 2; Homeobox protein MOX-2; meox2; MEOX2_HUMAN; Mesenchyme homeobox 2; MOX2;
免疫原
- P50222 MEOX2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEHPLFGCLRSPHATAQGLHPFSQSSLALHGRSDHMSYPELSTSSSSCIIAGYPNEEGMFASQHHRGHHHHHHHHHHHHHQQQQHQALQTNWHLPQMSSPPSAARHSLCLQPDSGGPPELGSSPPVLCSNSSSLGSSTPTGAACAPGDYGRQALSPAEAEKRSGGKRKSDSSDSQEGNYKSEVNSKPRKERTAFTKEQIRELEAEFAHHNYLTRLRRYEIAVNLDLTERQVKVWFQNRRMKWKRVKGGQQGAAAREKELVNVKKGTLLPSELSGIGAATLQQTGDSIANEDSHDSDHSSEHAHL
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P50222 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S155 | Phosphorylation | Uniprot | |
| S171 | Phosphorylation | Uniprot | |
| S172 | Phosphorylation | Uniprot | |
| S185 | Phosphorylation | Uniprot |
研究背景
Mesodermal transcription factor that plays a key role in somitogenesis and is required for sclerotome development (By similarity). Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle.
Nucleus. Nucleus speckle.
Embryo and placenta.
Interacts with RNF10.
The polyhistidine repeat may act as a targeting signal to nuclear speckles.
参考文献
Application: IHC Species: Human Sample: breast cancer tissues
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