AFfirm™ FGFP1 Mouse Monoclonal Antibody - #BF9620

製品: FGFP1 Mouse Monoclonal Antibody
カタログ: BF9620
タンパク質の説明: Mouse monoclonal antibody to FGFP1
アプリケーション: WB
反応性: Human
予測: Bovine
分子量: 26-38kD; 26kD(Calculated).
ユニプロット: Q14512

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IHC Protocol
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製品説明

ソース:
Mouse
アプリケーション:
WB 1:500-1:3000
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human
クローナリティ:
Monoclonal [AFfirm9620]
特異性:
FGFP1 Mouse Monoclonal Antibody detects endogenous levels of total FGFP1.
コンジュゲート:
Unconjugated.
精製:
Affinity-chromatography.
保存:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

17 kDa HBGF-binding protein; 17 kDa heparin binding growth factor binding protein; 17 kDa heparin-binding growth factor-binding protein; FGF binding protein 1; FGF BP; FGF BP1; FGF-binding protein 1; FGF-BP; FGF-BP1; FGFBP; FGFBP-1; Fgfbp1; FGFP1_HUMAN; Fibroblast growth factor binding protein 1 precursor; Fibroblast growth factor-binding protein 1; HBp17;

免疫原

免疫原:

A synthesized peptide derived from human FGFP1, corresponding to a region within C-terminal amino acids.

Uniprot:

Q14512(FGFP1_HUMAN) >>Visit HPA database.

遺伝子(ID):
FGFBP1(9982)
発現特異性:
Q14512 FGFP1_HUMAN:

Expressed in the suprabasal region of the epidermis, in hair follicles, the basement membrane at the dermo-epidermal junction (occasionally extending into the basement membrane of dermal blood vessels), wounded skin and several invasive squamous cell carcinomas (at protein level). Expressed in normal and wounded skin and various squamous cell carcinomas.

タンパク質配列:
MKICSLTLLSFLLLAAQVLLVEGKKKVKNGLHSKVVSEQKDTLGNTQIKQKSRPGNKGKFVTKDQANCRWAATEQEEGISLKVECTQLDHEFSCVFAGNPTSCLKLKDERVYWKQVARNLRSQKDICRYSKTAVKTRVCRKDFPESSLKLVSSTLFGNTKPRKEKTEMSPREHIKGKETTPSSLAVTQTMATKAPECVEDPDMANQRKTALEFCGETWSSLCTFFLSIVQDTSC

研究背景

機能:

Acts as a carrier protein that release fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth.

細胞の位置付け:

Secreted>Extracellular space. Cell membrane>Peripheral membrane protein.
Note: Extracellular and plasma membrane-associated. Colocalizes with HSPG2 in the pericellular environment of squamous cell carcinomas.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Expressed in the suprabasal region of the epidermis, in hair follicles, the basement membrane at the dermo-epidermal junction (occasionally extending into the basement membrane of dermal blood vessels), wounded skin and several invasive squamous cell carcinomas (at protein level). Expressed in normal and wounded skin and various squamous cell carcinomas.

タンパク質ファミリー:

Belongs to the fibroblast growth factor-binding protein family.

Restrictive clause

 

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