MYST2 Antibody - #DF3056
(1)
(4)
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF3056, RRID:AB_2835439.
折りたたみ／展開
Hbo 1; HBO1; HBOa; Histone acetyltransferase binding to hORC1; Histone acetyltransferase binding to ORC1; Histone acetyltransferase KAT7; Histone acetyltransferase MYST2; K(lysine) acetyltransferase 7; KAT 7; KAT7; Lysine acetyltransferase 7; MOZ; MOZ YBF2/SAS3 SAS2 and TIP60 protein; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2; MYST 2; MYST histone acetyltransferase 2; MYST protein 2; MYST-2; MYST2; MYST2_HUMAN; SAS 2; SAS2 and TIP60 protein 2; TIP60 protein 2; YBF2/SAS3; ZC2HC7;
免疫原
- O95251 KAT7_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPRRKRNAGSSSDGTEDSDFSTDLEHTDSSESDGTSRRSARVTRSSARLSQSSQDSSPVRNLQSFGTEEPAYSTRRVTRSQQQPTPVTPKKYPLRQTRSSGSETEQVVDFSDRETKNTADHDESPPRTPTGNAPSSESDIDISSPNVSHDESIAKDMSLKDSGSDLSHRPKRRRFHESYNFNMKCPTPGCNSLGHLTGKHERHFSISGCPLYHNLSADECKVRAQSRDKQIEERMLSHRQDDNNRHATRHQAPTERQLRYKEKVAELRKKRNSGLSKEQKEKYMEHRQTYGNTREPLLENLTSEYDLDLFRRAQARASEDLEKLRLQGQITEGSNMIKTIAFGRYELDTWYHSPYPEEYARLGRLYMCEFCLKYMKSQTILRRHMAKCVWKHPPGDEIYRKGSISVFEVDGKKNKIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVMTEADNTGCHLIGYFSKEKNSFLNYNVSCILTMPQYMRQGYGKMLIDFSYLLSKVEEKVGSPERPLSDLGLISYRSYWKEVLLRYLHNFQGKEISIKEISQETAVNPVDIVSTLQALQMLKYWKGKHLVLKRQDLIDEWIAKEAKRSNSNKTMDPSCLKWTPPKGT
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O95251 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S10 | Phosphorylation | Uniprot | |
| T15 | Phosphorylation | Uniprot | |
| S18 | Phosphorylation | Uniprot | |
| T22 | Phosphorylation | Uniprot | |
| S39 | Phosphorylation | Uniprot | |
| S45 | Phosphorylation | Uniprot | |
| S46 | Phosphorylation | Uniprot | |
| S50 | Phosphorylation | Uniprot | |
| S52 | Phosphorylation | Uniprot | |
| S53 | Phosphorylation | Uniprot | |
| S56 | Phosphorylation | Uniprot | |
| S57 | Phosphorylation | P53350 (PLK1) | Uniprot |
| S64 | Phosphorylation | Uniprot | |
| T67 | Phosphorylation | Uniprot | |
| Y72 | Phosphorylation | Uniprot | |
| T74 | Phosphorylation | Uniprot | |
| T78 | Phosphorylation | Uniprot | |
| S80 | Phosphorylation | Uniprot | |
| T85 | Phosphorylation | P06493 (CDK1) | Uniprot |
| T88 | Phosphorylation | P06493 (CDK1) , P24941 (CDK2) | Uniprot |
| K90 | Ubiquitination | Uniprot | |
| T97 | Phosphorylation | Uniprot | |
| S99 | Phosphorylation | Uniprot | |
| S100 | Phosphorylation | Uniprot | |
| S102 | Phosphorylation | Uniprot | |
| T104 | Phosphorylation | Uniprot | |
| S111 | Phosphorylation | Uniprot | |
| T115 | Phosphorylation | Uniprot | |
| T118 | Phosphorylation | Uniprot | |
| S124 | Phosphorylation | Uniprot | |
| T128 | Phosphorylation | Uniprot | |
| T130 | Phosphorylation | Uniprot | |
| S135 | Phosphorylation | Uniprot | |
| S136 | Phosphorylation | Uniprot | |
| S138 | Phosphorylation | Uniprot | |
| S158 | Phosphorylation | Uniprot | |
| K160 | Acetylation | Uniprot | |
| S162 | Phosphorylation | Uniprot | |
| S164 | Phosphorylation | Uniprot | |
| S167 | Phosphorylation | Uniprot | |
| K171 | Acetylation | Uniprot | |
| S178 | Phosphorylation | Uniprot | |
| K184 | Sumoylation | Uniprot | |
| T187 | Phosphorylation | Uniprot | |
| S192 | Phosphorylation | Uniprot | |
| K199 | Acetylation | Uniprot | |
| S205 | Phosphorylation | Uniprot | |
| Y212 | Phosphorylation | Uniprot | |
| S216 | Phosphorylation | Uniprot | |
| K221 | Acetylation | Uniprot | |
| K221 | Ubiquitination | Uniprot | |
| K229 | Acetylation | Uniprot | |
| K261 | Acetylation | Uniprot | |
| K269 | Acetylation | Uniprot | |
| K270 | Acetylation | Uniprot | |
| K277 | Acetylation | Uniprot | |
| K323 | Acetylation | Uniprot | |
| K323 | Ubiquitination | Uniprot | |
| T331 | Phosphorylation | Uniprot | |
| S334 | Phosphorylation | Uniprot | |
| K338 | Ubiquitination | Uniprot | |
| T339 | Phosphorylation | Uniprot | |
| K376 | Methylation | Uniprot | |
| K376 | Ubiquitination | Uniprot | |
| Y399 | Phosphorylation | Uniprot | |
| S403 | Phosphorylation | Uniprot | |
| K432 | Acetylation | Uniprot | |
| S466 | Phosphorylation | Uniprot | |
| S506 | Phosphorylation | Uniprot | |
| S512 | Phosphorylation | Uniprot | |
| K524 | Ubiquitination | Uniprot | |
| K537 | Ubiquitination | Uniprot | |
| S540 | Phosphorylation | Uniprot | |
| S545 | Phosphorylation | Uniprot | |
| K587 | Ubiquitination | Uniprot | |
| K596 | Acetylation | Uniprot | |
| T606 | Phosphorylation | Uniprot | |
| K609 | Ubiquitination | Uniprot | |
| T611 | Phosphorylation | Uniprot |
研究背景
Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Involved in H3K14 (histone H3 lysine 14) acetylation and cell proliferation (By similarity). Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Acts as a coactivator of the licensing factor CDT1. Specifically represses AR-mediated transcription.
Phosphorylation at Ser-57 by PLK1 during mitosis seems important for prereplicative complex formation and DNA replication licensing, and requires prior phosphorylation at Thr-85 and Thr-88 by CDK1. Phosphorylated by MAP2K1, which accelerates its degradation (By similarity).
Autoacetylation at Lys-432 is required for proper function.
Ubiquitinated at Lys-338, leading to proteasomal degradation.
Nucleus>Nucleoplasm. Cytoplasm>Cytosol. Nucleus.
Note: Associates with replication origins specifically during the G1 phase of the cell cycle (PubMed:18832067).
Ubiquitously expressed, with highest levels in testis.
Component of the HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3. Interacts with MCM2 and ORC1. Interacts with the androgen receptor (AR) in the presence of dihydrotestosterone. Interacts with CDT1. Interacts with MAP2K1 and CUL1 (By similarity).
The C2HC MYST-type zinc finger is required for interaction with MCM2 and ORC1.
The N-terminus is involved in transcriptional repression, while the C-terminus mediates AR-interaction.
Belongs to the MYST (SAS/MOZ) family.
参考文献
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