TBX 2/3 Antibody - #AF0319
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF0319, RRID:AB_2833482.
折りたたみ／展開
Bladder cancer related protein XHL; T box 2; T box 3; T box protein 2; T box protein 3; T box transcription factor TBX2; T box transcription factor TBX3; TBX3-ISO; UMS; XHL; FLJ10169; HGNC:11597; T box 2; T box transcription factor TBX2; T-box protein 2; T-box transcription factor TBX2; TBX2; TBX2_HUMAN;
免疫原
Widely expressed.
Q13207 TBX2_HUMAN:Expressed primarily in adult in kidney, lung, and placenta. Weak expression in heart and ovary.
- O15119 TBX3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSLSMRDPVIPGTSMAYHPFLPHRAPDFAMSAVLGHQPPFFPALTLPPNGAAALSLPGALAKPIMDQLVGAAETGIPFSSLGPQAHLRPLKTMEPEEEVEDDPKVHLEAKELWDQFHKRGTEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIIAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSPATGEQWMSKVVTFHKLKLTNNISDKHGFTLAFPSDHATWQGNYSFGTQTILNSMHKYQPRFHIVRANDILKLPYSTFRTYLFPETEFIAVTAYQNDKITQLKIDNNPFAKGFRDTGNGRREKRKQLTLQSMRVFDERHKKENGTSDESSSEQAAFNCFAQASSPAASTVGTSNLKDLCPSEGESDAEAESKEEHGPEACDAAKISTTTSEEPCRDKGSPAVKAHLFAAERPRDSGRLDKASPDSRHSPATISSSTRGLGAEERRSPVREGTAPAKVEEARALPGKEAFAPLTVQTDAAAAHLAQGPLPGLGFAPGLAGQQFFNGHPLFLHPSQFAMGGAFSSMAAAGMGPLLATVSGASTGVSGLDSTAMASAAAAQGLSGASAATLPFHLQQHVLASQGLAMSPFGSLFPYPYTYMAAAAAASSAAASSSVHRHPFLNLNTMRPRLRYSPYSIPVPVPDGSSLLTTALPSMAAAAGPLDGKVAALAASPASVAVDSGSELNSRSSTLSSSSMSLSPKLCAEKEAATSELQSIQRLVSGLEAKPDRSRSASP
- Q13207 TBX2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MREPALAASAMAYHPFHAPRPADFPMSAFLAAAQPSFFPALALPPGALAKPLPDPGLAGAAAAAAAAAAAAEAGLHVSALGPHPPAAHLRSLKSLEPEDEVEDDPKVTLEAKELWDQFHKLGTEMVITKSGRRMFPPFKVRVSGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSPATGEQWMAKPVAFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVRANDILKLPYSTFRTYVFPETDFIAVTAYQNDKITQLKIDNNPFAKGFRDTGNGRREKRKQLTLPSLRLYEEHCKPERDGAESDASSCDPPPAREPPTSPGAAPSPLRLHRARAEEKSCAADSDPEPERLSEERAGAPLGRSPAPDSASPTRLTEPERARERRSPERGKEPAESGGDGPFGLRSLEKERAEARRKDEGRKEAAEGKEQGLAPLVVQTDSASPLGAGHLPGLAFSSHLHGQQFFGPLGAGQPLFLHPGQFTMGPGAFSAMGMGHLLASVAGGGNGGGGGPGTAAGLDAGGLGPAASAASTAAPFPFHLSQHMLASQGIPMPTFGGLFPYPYTYMAAAAAAASALPATSAAAAAAAAAGSLSRSPFLGSARPRLRFSPYQIPVTIPPSTSLLTTGLASEGSKAAGGNSREPSPLPELALRKVGAPSRGALSPSGSAKEAANELQSIQRLVSGLESQRALSPGRESPK
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O15119/Q13207 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K104 | Ubiquitination | Uniprot | |
| K110 | Ubiquitination | Uniprot | |
| K118 | Ubiquitination | Uniprot | |
| T121 | Phosphorylation | Uniprot | |
| K127 | Ubiquitination | Uniprot | |
| Y163 | Phosphorylation | Uniprot | |
| Y185 | Phosphorylation | Uniprot | |
| S190 | Phosphorylation | Uniprot | |
| T203 | Phosphorylation | Uniprot | |
| K206 | Ubiquitination | Uniprot | |
| K208 | Ubiquitination | Uniprot | |
| Y265 | Phosphorylation | Uniprot | |
| K293 | Ubiquitination | Uniprot | |
| K301 | Ubiquitination | Uniprot | |
| K313 | Ubiquitination | Uniprot | |
| S371 | Phosphorylation | Uniprot | |
| S375 | Phosphorylation | Uniprot | |
| S381 | Phosphorylation | Uniprot | |
| S396 | Phosphorylation | Uniprot | |
| S400 | Phosphorylation | Uniprot | |
| S409 | Phosphorylation | Uniprot | |
| K413 | Ubiquitination | Uniprot | |
| S432 | Phosphorylation | Uniprot | |
| S435 | Phosphorylation | Uniprot | |
| S438 | Phosphorylation | Uniprot | |
| T441 | Phosphorylation | Uniprot | |
| S443 | Phosphorylation | Uniprot | |
| S444 | Phosphorylation | Uniprot | |
| S445 | Phosphorylation | Uniprot | |
| T446 | Phosphorylation | Uniprot | |
| S456 | Phosphorylation | Uniprot | |
| T462 | Phosphorylation | Uniprot | |
| K466 | Ubiquitination | Uniprot | |
| S680 | Phosphorylation | Uniprot | |
| S707 | Phosphorylation | Uniprot | |
| K714 | Ubiquitination | Uniprot | |
| T718 | Phosphorylation | Uniprot | |
| S719 | Phosphorylation | Q9Y243 (AKT3) | Uniprot |
| S729 | Phosphorylation | Uniprot | |
| K734 | Ubiquitination | Uniprot | |
| S738 | Phosphorylation | Uniprot | |
| S740 | Phosphorylation | Uniprot | |
| S742 | Phosphorylation | Uniprot |
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S94 | Phosphorylation | Uniprot | |
| Y165 | Phosphorylation | Uniprot | |
| K210 | Ubiquitination | Uniprot | |
| Y247 | Phosphorylation | Uniprot | |
| T252 | Phosphorylation | Uniprot | |
| Y253 | Phosphorylation | Uniprot | |
| T258 | Phosphorylation | Uniprot | |
| K275 | Ubiquitination | Uniprot | |
| K283 | Ubiquitination | Uniprot | |
| K295 | Ubiquitination | Uniprot | |
| S320 | Phosphorylation | Uniprot | |
| S323 | Phosphorylation | Uniprot | |
| S324 | Phosphorylation | Uniprot | |
| S336 | Phosphorylation | Uniprot | |
| S342 | Phosphorylation | Uniprot | |
| S360 | Phosphorylation | Uniprot | |
| S368 | Phosphorylation | Uniprot | |
| S379 | Phosphorylation | Uniprot | |
| S384 | Phosphorylation | Uniprot | |
| S386 | Phosphorylation | Uniprot | |
| T391 | Phosphorylation | Uniprot | |
| S401 | Phosphorylation | Uniprot | |
| S635 | Phosphorylation | Uniprot | |
| T638 | Phosphorylation | Uniprot | |
| S643 | Phosphorylation | Uniprot | |
| S646 | Phosphorylation | Uniprot | |
| S653 | Phosphorylation | Uniprot | |
| S657 | Phosphorylation | Uniprot | |
| S676 | Phosphorylation | Uniprot | |
| S705 | Phosphorylation | Uniprot | |
| S710 | Phosphorylation | Uniprot |
研究背景
Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence.
Nucleus.
Widely expressed.
Interacts with PML (isoform PML-4).
Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence. May be required for cardiac atrioventricular canal formation.
Nucleus.
Expressed primarily in adult in kidney, lung, and placenta. Weak expression in heart and ovary.
Interacts with PML (isoform-PML-2, isoform PML-3 and isoform PML-4).
The repression domain 1 (RD1) is necessary for its interaction with PML.
研究領域
· Cellular Processes > Cellular community - eukaryotes > Signaling pathways regulating pluripotency of stem cells. (View pathway)
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