CTSK Recombinant Rabbit mAb - #BF3166

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製品: CTSK Recombinant Rabbit mAb
カタログ: BF3166
タンパク質の説明: Rabbit monoclonal antibody to CTSK
アプリケーション: WB IHC
反応性: Human, Mouse, Rat
分子量: 37 kDa(Observed); 37kD(Calculated).
ユニプロット: P43235

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説明書
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WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit IgG
アプリケーション:
WB 1:1000-1:5000, IHC 1:200-1:1000
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
クローナリティ:
Monoclonal [ReFirm22613]
特異性:
CTSK Recombinant Rabbit mAb detects endogenous levels of CTSK.
コンジュゲート:
Unconjugated.
精製:
Affinity-chromatography.
保存:
Rabbit IgG in Tris-Glycine (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

Cathepsin K; Cathepsin O; Cathepsin O1; Cathepsin O2; Cathepsin X; CATK_HUMAN; CTS02; Ctsk; CTSO; CTSO1; CTSO2; MGC23107; PKND; PYCD;

免疫原

免疫原:

A synthetic peptide from human CTSK

Uniprot:

P43235(CATK_HUMAN) >>Visit HPA database.

遺伝子(ID):
CTSK(1513)
発現特異性:
P43235 CATK_HUMAN:

Predominantly expressed in osteoclasts (bones) (PubMed:7805878). Expressed in thyroid epithelial cells (PubMed:11082042).

タンパク質の説明:
The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein,which is a member of the peptidase C1 protein family,is predominantly expressed in osteoclasts. However,the encoded protein is also expressed in a significant fraction of human breast cancers,where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis,an autosomal recessive disease characterized by osteosclerosis and short stature.
タンパク質配列:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM

研究背景

機能:

Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen.

細胞の位置付け:

Lysosome. Secreted. Apical cell membrane>Peripheral membrane protein>Extracellular side.
Note: Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Predominantly expressed in osteoclasts (bones). Expressed in thyroid epithelial cells.

タンパク質ファミリー:

Belongs to the peptidase C1 family.

研究領域

· Cellular Processes > Transport and catabolism > Lysosome.   (View pathway)

· Cellular Processes > Cell growth and death > Apoptosis.   (View pathway)

· Human Diseases > Immune diseases > Rheumatoid arthritis.

· Organismal Systems > Development > Osteoclast differentiation.   (View pathway)

· Organismal Systems > Immune system > Toll-like receptor signaling pathway.   (View pathway)

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