CDC2L1 Antibody - #DF3118
| 製品: | CDC2L1 Antibody |
| カタログ: | DF3118 |
| タンパク質の説明: | Rabbit polyclonal antibody to CDC2L1 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse |
| 予測: | Pig, Bovine, Xenopus |
| 分子量: | 92 KD; 93kD(Calculated). |
| ユニプロット: | P21127 |
| RRID: | AB_2835495 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF3118, RRID:AB_2835495.
折りたたみ／展開
CDC2L1; CDK11; Cell division cycle 2-like protein kinase 1; Cell division protein kinase 11B; CLK 1; EC=2.7.11.22; Galactosyltransferase associated protein kinase p58/GTA; ITSLRE serine/threonine protein kinase CDC2L1; p58 CLK 1; PITSLREA; PK58;
免疫原
- P21127 CD11B_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPGEARPAPAQKPAQLKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P21127 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K11 | Sumoylation | Uniprot | |
| K11 | Ubiquitination | Uniprot | |
| K20 | Sumoylation | Uniprot | |
| K20 | Ubiquitination | Uniprot | |
| K29 | Sumoylation | Uniprot | |
| S43 | Phosphorylation | Uniprot | |
| S47 | Phosphorylation | Uniprot | |
| T61 | Phosphorylation | Uniprot | |
| S65 | Phosphorylation | Uniprot | |
| Y67 | Phosphorylation | Uniprot | |
| S72 | Phosphorylation | Uniprot | |
| K101 | Acetylation | Uniprot | |
| S113 | Phosphorylation | Uniprot | |
| S115 | Phosphorylation | Uniprot | |
| K135 | Acetylation | Uniprot | |
| S212 | Phosphorylation | Uniprot | |
| Y222 | Phosphorylation | Uniprot | |
| S223 | Phosphorylation | Uniprot | |
| K225 | Acetylation | Uniprot | |
| S229 | Phosphorylation | Uniprot | |
| S232 | Phosphorylation | Uniprot | |
| S234 | Phosphorylation | Uniprot | |
| K266 | Sumoylation | Uniprot | |
| S277 | Phosphorylation | Uniprot | |
| S283 | Phosphorylation | Uniprot | |
| S285 | Phosphorylation | Uniprot | |
| S358 | Phosphorylation | Uniprot | |
| S381 | Phosphorylation | Uniprot | |
| S384 | Phosphorylation | Uniprot | |
| T395 | Phosphorylation | Uniprot | |
| T402 | Phosphorylation | Uniprot | |
| Y406 | Phosphorylation | Uniprot | |
| S410 | Phosphorylation | Uniprot | |
| S414 | Phosphorylation | Uniprot | |
| K419 | Sumoylation | Uniprot | |
| K424 | Ubiquitination | Uniprot | |
| S434 | Phosphorylation | Uniprot | |
| T448 | Phosphorylation | Uniprot | |
| Y449 | Phosphorylation | Uniprot | |
| Y453 | Phosphorylation | Uniprot | |
| K456 | Acetylation | Uniprot | |
| K458 | Acetylation | Uniprot | |
| K459 | Acetylation | Uniprot | |
| K459 | Sumoylation | Uniprot | |
| K459 | Ubiquitination | Uniprot | |
| K467 | Acetylation | Uniprot | |
| K467 | Sumoylation | Uniprot | |
| K467 | Ubiquitination | Uniprot | |
| K475 | Ubiquitination | Uniprot | |
| S482 | Phosphorylation | Uniprot | |
| T488 | Phosphorylation | Uniprot | |
| K491 | Sumoylation | Uniprot | |
| K491 | Ubiquitination | Uniprot | |
| K531 | Ubiquitination | Uniprot | |
| K551 | Ubiquitination | Uniprot | |
| K564 | Sumoylation | Uniprot | |
| K564 | Ubiquitination | Uniprot | |
| K577 | Ubiquitination | Uniprot | |
| Y587 | Phosphorylation | Uniprot | |
| S589 | Phosphorylation | Uniprot | |
| Y594 | Phosphorylation | Uniprot | |
| T595 | Phosphorylation | P50613 (CDK7) | Uniprot |
| T600 | Phosphorylation | Uniprot | |
| K641 | Sumoylation | Uniprot | |
| K641 | Ubiquitination | Uniprot | |
| K649 | Sumoylation | Uniprot | |
| K649 | Ubiquitination | Uniprot | |
| K652 | Sumoylation | Uniprot | |
| K652 | Ubiquitination | Uniprot | |
| K660 | Ubiquitination | Uniprot | |
| K672 | Ubiquitination | Uniprot | |
| K673 | Sumoylation | Uniprot | |
| K673 | Ubiquitination | Uniprot | |
| T675 | Phosphorylation | Uniprot | |
| S713 | Phosphorylation | Uniprot | |
| K719 | Sumoylation | Uniprot | |
| K719 | Ubiquitination | Uniprot | |
| T726 | Phosphorylation | Q9UQ88 (CDK11A) | Uniprot |
| K741 | Sumoylation | Uniprot | |
| K741 | Ubiquitination | Uniprot | |
| T751 | Phosphorylation | Uniprot | |
| S752 | Phosphorylation | O96017 (CHEK2) | Uniprot |
| Y762 | Phosphorylation | Uniprot | |
| S763 | Phosphorylation | Uniprot | |
| T773 | Phosphorylation | Uniprot | |
| T778 | Phosphorylation | Uniprot | |
| S785 | Phosphorylation | Uniprot | |
| S792 | Phosphorylation | Uniprot | |
| K794 | Methylation | Uniprot | |
| K794 | Sumoylation | Uniprot | |
| K794 | Ubiquitination | Uniprot |
研究背景
Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression.
During FAS- or TNF-induced apoptosis, isoform SV9 is cleaved by caspases to produce p110C, a fragment that contains the C-terminal kinase domain.
Phosphorylation at Ser-115 creates a binding site for 14-3-3 proteins. p110C can be autophosphorylated.
Cytoplasm. Nucleus.
Expressed ubiquitously. Some evidence of isoform-specific tissue distribution.
Cleaved isoform SV9 (p110C) binds to the serine/threonine kinase PAK1 and RANBP9. p110C interacts with RNPS1. Isoform 7, but not isoform SV9, nor its cleavage product p110C, interacts with CCND3. Interacts with CCNL1 and CCNL2. Forms complexes with pre-mRNA-splicing factors, including at least SRSF1, SRSF2 AND SRSF7/SLU7. Interacts with isoform 5 of MYO18A.
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
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