CSTF2 Antibody - #DF3158
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF3158, RRID:AB_2835535.
折りたたみ／展開
betaCstF 64 variant 2; CF-1 64 kDa subunit; CF1 64 kDa subunit; Cleavage stimulation factor 64 kDa subunit; Cleavage stimulation factor subunit 2; Cleavage stimulation factor, 3' pre RNA, subunit 2, 64kDa; CSTF 2; CstF 64; CSTF 64 kDa subunit; CstF-64; CSTF2; CSTF2_HUMAN; MGC188397;
免疫原
- P33240 CSTF2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAGLTVRDPAVDRSLRSVFVGNIPYEATEEQLKDIFSEVGPVVSFRLVYDRETGKPKGYGFCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELKSLGTGAPVIESPYGETISPEDAPESISKAVASLPPEQMFELMKQMKLCVQNSPQEARNMLLQNPQLAYALLQAQVVMRIVDPEIALKILHRQTNIPTLIAGNPQPVHGAGPGSGSNVSMNQQNPQAPQAQSLGGMHVNGAPPLMQASMQGGVPAPGQMPAAVTGPGPGSLAPGGGMQAQVGMPGSGPVSMERGQVPMQDPRAAMQRGSLPANVPTPRGLLGDAPNDPRGGTLLSVTGEVEPRGYLGPPHQGPPMHHVPGHESRGPPPHELRGGPLPEPRPLMAEPRGPMLDQRGPPLDGRGGRDPRGIDARGMEARAMEARGLDARGLEARAMEARAMEARAMEARAMEARAMEVRGMEARGMDTRGPVPGPRGPIPSGMQGPSPINMGAVVPQGSRQVPVMQGTGMQGASIQGGSQPGGFSPGQNQVTPQDHEKAALIMQVLQLTADQIAMLPPEQRQSILILKEQIQKSTGAP
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P33240 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S14 | Phosphorylation | Uniprot | |
| K96 | Ubiquitination | Uniprot | |
| S113 | Phosphorylation | Uniprot | |
| Y115 | Phosphorylation | Uniprot | |
| T118 | Phosphorylation | Uniprot | |
| S120 | Phosphorylation | Uniprot | |
| K130 | Ubiquitination | Uniprot | |
| K145 | Ubiquitination | Uniprot | |
| K148 | Ubiquitination | Uniprot | |
| S154 | Phosphorylation | Uniprot | |
| K189 | Ubiquitination | Uniprot | |
| R303 | Methylation | Uniprot | |
| R308 | Methylation | Uniprot | |
| S310 | Phosphorylation | Uniprot | |
| T317 | Phosphorylation | Uniprot | |
| R319 | Methylation | Uniprot | |
| R330 | Methylation | Uniprot | |
| T333 | Phosphorylation | Uniprot | |
| S336 | Phosphorylation | Uniprot | |
| T338 | Phosphorylation | Uniprot | |
| R344 | Methylation | Uniprot | |
| R365 | Methylation | Uniprot | |
| R373 | Methylation | Uniprot | |
| R381 | Methylation | Uniprot | |
| R388 | Methylation | Uniprot | |
| R402 | Methylation | Uniprot | |
| R405 | Methylation | Uniprot | |
| R423 | Methylation | Uniprot | |
| R428 | Methylation | Uniprot | |
| R458 | Methylation | Uniprot | |
| R463 | Methylation | Uniprot | |
| R468 | Methylation | Uniprot | |
| R475 | Methylation | Uniprot | |
| S480 | Phosphorylation | Uniprot | |
| S486 | Phosphorylation | Uniprot | |
| S498 | Phosphorylation | Uniprot | |
| R499 | Methylation | Uniprot | |
| T507 | Phosphorylation | Uniprot | |
| S518 | Phosphorylation | Uniprot | |
| S524 | Phosphorylation | Uniprot | |
| T531 | Phosphorylation | Uniprot | |
| S562 | Phosphorylation | Uniprot | |
| K567 | Ubiquitination | Uniprot | |
| K572 | Ubiquitination | Uniprot |
研究背景
One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs (By similarity).
Nucleus.
Note: Localized with DDX1 in cleavage bodies.
The CSTF complex is composed of CSTF1 (50 kDa subunit), CSTF2 (64 kDa subunit) and CSTF3 (77 kDa subunit). CSTF2 directly interacts with CSTF3, SYMPK and RPO2TC1. Interacts with HSF1 in heat-stressed cells. Interacts with CPSF2, CPSF3 and FIP1L1. Interacts with DDX1.
研究領域
· Genetic Information Processing > Translation > mRNA surveillance pathway.
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