CRH Recombinant Rabbit mAb - #BF3584

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製品: CRH Recombinant Rabbit mAb
カタログ: BF3584
タンパク質の説明: Rabbit monoclonal antibody to CRH
アプリケーション: WB
反応性: Human, Mouse, Rat
分子量: 21 kDa(Observed); 21kD(Calculated).
ユニプロット: P06850

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製品説明

ソース:
Rabbit IgG
アプリケーション:
WB 1:1000
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
クローナリティ:
Monoclonal [ReFirm23031]
特異性:
CRH Recombinant Rabbit mAb detects endogenous levels of CRH.
コンジュゲート:
Unconjugated.
精製:
Affinity-chromatography.
保存:
Rabbit IgG in Tris-Glycine (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

Corticoliberin; Corticotropin releasing factor; Corticotropin releasing hormone; CRF; Crh; CRH1;

免疫原

免疫原:

A synthetic peptide from human CRH

Uniprot:

P06850(CRF_HUMAN) >>Visit HPA database.

遺伝子(ID):
CRH(1392)
発現特異性:
P06850 CRF_HUMAN:

Produced by the hypothalamus and placenta.

タンパク質の説明:
This gene encodes a member of the corticotropin-releasing factor family. The encoded preproprotein is proteolytically processed to generate the mature neuropeptide hormone. In response to stress,this hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus,binds to corticotropin releasing hormone receptors and stimulates the release of adrenocorticotropic hormone from the pituitary gland. Marked reduction in this protein has been observed in association with Alzheimer's disease. Autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus,this protein is also synthesized in peripheral tissues,such as T lymphocytes,and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition,suggesting that,in addition to its metabolic functions,this protein may act as a trigger for parturition.
タンパク質配列:
MRLPLLVSAGVLLVALLPCPPCRALLSRGPVPGARQAPQHPQPLDFFQPPPQSEQPQQPQARPVLLRMGEEYFLRLGNLNKSPAAPLSPASSLLAGGSGSRPSPEQATANFFRVLLQQLLLPRRSLDSPAALAERGARNALGGHQEAPERERRSEEPPISLDLTFHLLREVLEMARAEQLAQQAHSNRKLMEIIGK

研究背景

機能:

Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity).

細胞の位置付け:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Produced by the hypothalamus and placenta.

タンパク質ファミリー:

Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.

研究領域

· Human Diseases > Substance dependence > Alcoholism.

· Organismal Systems > Nervous system > Long-term depression.

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