AGTR2 Recombinant Rabbit mAb - #BF3720

WB 1:1000-1:5000
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Human,Mouse,Rat

Monoclonal [ReFirm23167]

AGTR2 Recombinant Rabbit mAb detects endogenous levels of AGTR2.

Unconjugated.

Affinity-chromatography.

Rabbit IgG in Tris-Glycine (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.

P50052(AGTR2_HUMAN) >>Visit HPA database.

P50052 AGTR2_HUMAN:

In adult, highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. Expressed in the cerebellum. Very highly expressed in fetal kidney and intestine.

The protein encoded by this gene belongs to the G-protein coupled receptor 1 family,and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus,but scantily in adult tissues,except brain,adrenal medulla,and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may play an important role in developmental biology and pathophysiology. Mutations in this gene are been associated with X-linked cognitive disability. Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and SARS-CoV-2 infection result in down-regulation of ACE2 (angiotensin converting enzyme-2) receptors which triggers serious inflammatory lesions,primarily in the lungs. The inflammatory reaction is mediated by angiotensin II derivatives,however,while the ACE2-angiotensin II-angiotensin AT1 receptor pathway contributes to the pathophysiology of ARDS (acute respiratory distress syndrome),the activation of the ACE-2-angiotensin(1-7)-angiotensin AT2 receptor and the ACE-2-angiotensin(1-7)-Mas receptor pathways have been shown to be protective.

•    P50052 AGTR2_HUMAN:
• Protein BLAST With
• NCBI/
• ExPASy/
• Uniprot

MKGNSTLATTSKNITSGLHFGLVNISGNNESTLNCSQKPSDKHLDAIPILYYIIFVIGFLVNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRESMSCRKSSSLREMETFVS