DKC1 Recombinant Rabbit mAb - #BF3942

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製品: DKC1 Recombinant Rabbit mAb
カタログ: BF3942
タンパク質の説明: Rabbit monoclonal antibody to DKC1
アプリケーション: WB IHC IF/ICC
反応性: Human, Mouse, Rat
分子量: 58 kDa(Observed); 58kD(Calculated).
ユニプロット: O60832

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製品説明

ソース:
Rabbit IgG
アプリケーション:
WB 1:1000-1:5000, IHC 1:50-1:100, ICC
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human, Mouse, Rat
クローナリティ:
Monoclonal [ReFirm23389]
特異性:
DKC1 Recombinant Rabbit mAb detects endogenous levels of DKC1.
コンジュゲート:
Unconjugated.
精製:
Affinity-chromatography.
保存:
Rabbit IgG in Tris-Glycine (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

DKC,CBF5,DKCX,NAP57,NOLA4,XAP101

免疫原

免疫原:

A synthetic peptide from human DKC1

Uniprot:

O60832(DKC1_HUMAN) >>Visit HPA database.

遺伝子(ID):
DKC1(1736)
発現特異性:
O60832 DKC1_HUMAN:

Ubiquitously expressed.

タンパク質の説明:
This gene functions in two distinct complexes. It plays an active role in telomerase stabilization and maintenance,as well as recognition of snoRNAs containing H,ACA sequences which provides stability during biogenesis and assembly into H,ACA small nucleolar RNA ribonucleoproteins (snoRNPs). This gene is highly conserved and widely expressed,and may play additional roles in nucleo-cytoplasmic shuttling,DNA damage response,and cell adhesion. Mutations have been associated with X-linked dyskeratosis congenita. Alternative splicing results in multiple transcript variants.
タンパク質配列:
MADAEVIILPKKHKKKKERKSLPEEDVAEIQHAEEFLIKPESKVAKLDTSQWPLLLKNFDKLNVRTTHYTPLACGSNPLKREIGDYIRTGFINLDKPSNPSSHEVVAWIRRILRVEKTGHSGTLDPKVTGCLIVCIERATRLVKSQQSAGKEYVGIVRLHNAIEGGTQLSRALETLTGALFQRPPLIAAVKRQLRVRTIYESKMIEYDPERRLGIFWVSCEAGTYIRTLCVHLGLLLGVGGQMQELRRVRSGVMSEKDHMVTMHDVLDAQWLYDNHKDESYLRRVVYPLEKLLTSHKRLVMKDSAVNAICYGAKIMLPGVLRYEDGIEVNQEIVVITTKGEAICMAIALMTTAVISTCDHGIVAKIKRVIMERDTYPRKWGLGPKASQKKLMIKQGLLDKHGKPTDSTPATWKQEYVDYSESAKKEVVAEVVKAPQVVAEAAKTAKRKRESESESDETPPAAPQLIKKEKKKSKKDKKAKAGLESGAEPGDGDSDTTKKKKKKKKAKEVELVSE

研究背景

機能:

Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.

Promotes cell to cell and cell to substratum adhesion, increases the cell proliferation rate and leads to cytokeratin hyper-expression.

細胞の位置付け:

Nucleus>Nucleolus. Nucleus>Cajal body.
Note: Also localized to Cajal bodies (coiled bodies).

Cytoplasm.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Ubiquitously expressed.

タンパク質ファミリー:

Belongs to the pseudouridine synthase TruB family.

研究領域

· Genetic Information Processing > Translation > Ribosome biogenesis in eukaryotes.

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