TSPO Recombinant Rabbit mAb - #BF3970

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製品: TSPO Recombinant Rabbit mAb
カタログ: BF3970
タンパク質の説明: Rabbit monoclonal antibody to TSPO
アプリケーション: WB IHC IF/ICC
反応性: Human, Mouse
分子量: 19 kDa(Observed); 19kD(Calculated).
ユニプロット: P30536

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製品説明

ソース:
Rabbit IgG
アプリケーション:
WB 1:2000-1:20000, IHC 1:100-1:1000, ICC
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human, Mouse
クローナリティ:
Monoclonal [ReFirm23417]
特異性:
TSPO Recombinant Rabbit mAb detects endogenous levels of TSPO.
コンジュゲート:
Unconjugated.
精製:
Affinity-chromatography.
保存:
Rabbit IgG in Tris-Glycine (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

DBI,IBP,MBR,PBR,PBS,BPBS,BZRP,PKBS,PTBR,mDRC,pk18

免疫原

免疫原:

A synthetic peptide from human TSPO

Uniprot:

P30536(TSPO_HUMAN) >>Visit HPA database.

遺伝子(ID):
TSPO(706)
発現特異性:
P30536 TSPO_HUMAN:

Found in many tissue types. Expressed at the highest levels under normal conditions in tissues that synthesize steroids.

タンパク質の説明:
Present mainly in the mitochondrial compartment of peripheral tissues,the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternatively spliced transcript variants have been reported,one of the variants lacks an internal exon and is considered non-coding,and the other variants encode the same protein.
タンパク質配列:
MAPPWVPAMGFTLAPSLGCFVGSRFVHGEGLRWYAGLQKPSWHPPHWVLGPVWGTLYSAMGYGSYLVWKELGGFTEKAVVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLLLVSGAAAATTVAWYQVSPLAARLLYPYLAWLAFTTTLNYCVWRDNHGWRGGRRLPE

研究背景

機能:

Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism, but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides.

細胞の位置付け:

Mitochondrion membrane>Multi-pass membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Found in many tissue types. Expressed at the highest levels under normal conditions in tissues that synthesize steroids.

タンパク質ファミリー:

Belongs to the TspO/BZRP family.

研究領域

· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.

· Human Diseases > Infectious diseases: Viral > HTLV-I infection.

· Organismal Systems > Digestive system > Cholesterol metabolism.

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