Lumican Recombinant Rabbit mAb - #BF3991
製品説明
ソース:
Rabbit IgG
アプリケーション:
WB 1:1000-1:5000, IHC 1:50-1:100, ICC
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
反応性:
Human, Mouse, Rat
クローナリティ:
Monoclonal [ReFirm23438]
特異性:
Lumican Recombinant Rabbit mAb detects endogenous levels of Lumican.
コンジュゲート:
Unconjugated.
精製:
Affinity-chromatography.
保存:
Rabbit IgG in Tris-Glycine (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:
折りたたみ／展開
LDC,SLRR2D
免疫原
免疫原:
A synthetic peptide from human Lumican
Uniprot:
遺伝子(ID):
発現特異性:
タンパク質の説明:
This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin,biglycan,fibromodulin,keratocan,epiphycan,and osteoglycin. In these bifunctional molecules,the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth,corneal transparency,and epithelial cell migration and tissue repair.
タンパク質配列:
- P51884 LUM_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSLSAFTLFLALIGGTSGQYYDYDFPLSIYGQSSPNCAPECNCPESYPSAMYCDELKLKSVPMVPPGIKYLYLRNNQIDHIDEKAFENVTDLQWLILDHNLLENSKIKGRVFSKLKQLKKLHINHNNLTESVGPLPKSLEDLQLTHNKITKLGSFEGLVNLTFIHLQHNRLKEDAVSAAFKGLKSLEYLDLSFNQIARLPSGLPVSLLTLYLDNNKISNIPDEYFKRFNALQYLRLSHNELADSGIPGNSFNVSSLVELDLSYNKLKNIPTVNENLENYYLEVNQLEKFDIKSFCKILGPLSYSKIKHLRLDGNRISETSLPPDMYECLRVANEVTLN
研究背景
PTMs:
Sulfated on tyrosine residue(s).
細胞の位置付け:
Secreted>Extracellular space>Extracellular matrix.
組織特異性:
Cornea and other tissues.
タンパク質ファミリー:
Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
研究領域
· Human Diseases > Cancers: Overview > Proteoglycans in cancer.
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