IPMK Antibody - #DF3359
| 製品: | IPMK Antibody |
| カタログ: | DF3359 |
| タンパク質の説明: | Rabbit polyclonal antibody to IPMK |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit |
| 分子量: | 47 KD; 47kD(Calculated). |
| ユニプロット: | Q8NFU5 |
| RRID: | AB_2835575 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF3359, RRID:AB_2835575.
折りたたみ／展開
3; 4; 6-tetrakisphosphate 5-kinase; Inositol 1; Inositol 1,3,4,6 tetrakisphosphate 5 kinase; Inositol polyphosphate multikinase; Ipmk; IPMK_HUMAN;
免疫原
Ubiquitous, with the highest expression in skeletal muscle, liver, placenta, lung, peripheral blood leukocytes, kidney, spleen and colon.
- Q8NFU5 IPMK_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MATEPPSPLRVEAPGPPEMRTSPAIESTPEGTPQPAGGRLRFLNGCVPLSHQVAGHMYGKDKVGILQHPDGTVLKQLQPPPRGPRELEFYNMVYAADCFDGVLLELRKYLPKYYGIWSPPTAPNDLYLKLEDVTHKFNKPCIMDVKIGQKSYDPFASSEKIQQQVSKYPLMEEIGFLVLGMRVYHVHSDSYETENQHYGRSLTKETIKDGVSRFFHNGYCLRKDAVAASIQKIEKILQWFENQKQLNFYASSLLFVYEGSSQPTTTKLNDRTLAEKFLSKGQLSDTEVLEYNNNFHVLSSTANGKIESSVGKSLSKMYARHRKIYTKKHHSQTSLKVENLEQDNGWKSMSQEHLNGNVLSQLEKVFYHLPTGCQEIAEVEVRMIDFAHVFPSNTIDEGYVYGLKHLISVLRSILDN
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q8NFU5 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| T3 | Phosphorylation | Uniprot | |
| S7 | Phosphorylation | Uniprot | |
| T21 | Phosphorylation | Uniprot | |
| S22 | Phosphorylation | Uniprot | |
| S27 | Phosphorylation | Uniprot | |
| T28 | Phosphorylation | Uniprot | |
| Y113 | Phosphorylation | Uniprot | |
| Y114 | Phosphorylation | Uniprot | |
| S118 | Phosphorylation | Uniprot | |
| K150 | Ubiquitination | Uniprot | |
| K160 | Ubiquitination | Uniprot | |
| K208 | Acetylation | Uniprot | |
| K223 | Ubiquitination | Uniprot | |
| S229 | Phosphorylation | Uniprot | |
| K232 | Ubiquitination | Uniprot | |
| T266 | Phosphorylation | Uniprot | |
| K312 | Ubiquitination | Uniprot | |
| Y318 | Phosphorylation | Uniprot | |
| Y325 | Phosphorylation | Uniprot | |
| T333 | Phosphorylation | Uniprot | |
| S334 | Phosphorylation | Uniprot | |
| S350 | Phosphorylation | Uniprot | |
| S360 | Phosphorylation | Uniprot | |
| S412 | Phosphorylation | Uniprot |
研究背景
Inositol phosphate kinase with a broad substrate specificity. Phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) first to inositol 1,3,4,5-tetrakisphosphate and then to inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5). Phosphorylates inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4). Phosphorylates glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate to glycero-3-phospho-1D-myo-inositol 3,4,5-trisphosphate. Plays an important role in MLKL-mediated necroptosis via its role in the biosynthesis of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Binding of these highly phosphorylated inositol phosphates to MLKL mediates the release of an N-terminal auto-inhibitory region, leading to activation of the kinase. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis. Required for normal embryonic development, probably via its role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) and inositol hexakisphosphate (InsP6) (By similarity).
Nucleus.
Ubiquitous, with the highest expression in skeletal muscle, liver, placenta, lung, peripheral blood leukocytes, kidney, spleen and colon.
Belongs to the inositol phosphokinase (IPK) family.
研究領域
· Environmental Information Processing > Signal transduction > Phosphatidylinositol signaling system.
· Metabolism > Carbohydrate metabolism > Inositol phosphate metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
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