Casein Kinase 2 beta Recombinant Rabbit mAb - #BF4185

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製品: Casein Kinase 2 beta Recombinant Rabbit mAb
カタログ: BF4185
タンパク質の説明: Rabbit monoclonal antibody to Casein Kinase 2 beta
アプリケーション: WB IHC IF/ICC
反応性: Human, Mouse, Rat
分子量: 25 kDa(Observed); 25kD(Calculated).
ユニプロット: P67870

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製品説明

ソース:
Rabbit IgG
アプリケーション:
WB 1:1000, IHC 1:100-1:200, ICC
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human, Mouse, Rat
クローナリティ:
Monoclonal [ReFirm23632]
特異性:
Casein Kinase 2 beta Recombinant Rabbit mAb detects endogenous levels of Casein Kinase 2 beta.
コンジュゲート:
Unconjugated.
精製:
Affinity-chromatography.
保存:
Rabbit IgG in Tris-Glycine (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

G5A,CK2B,CK2N,Ckb1,Ckb2,CSK2B,POBINDS

免疫原

免疫原:

A synthetic peptide from human Casein Kinase 2 beta

Uniprot:

P67870(CSK2B_HUMAN) >>Visit HPA database.

遺伝子(ID):
CSNK2B(1460)
タンパク質の説明:
This gene encodes the beta subunit of casein kinase II,a ubiquitous protein kinase which regulates metabolic pathways,signal transduction,transcription,translation,and replication. The enzyme is composed of three subunits,alpha,alpha prime and beta,which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic,while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene.
タンパク質配列:
MSSSEEVSWISWFCGLRGNEFFCEVDEDYIQDKFNLTGLNEQVPHYRQALDMILDLEPDEELEDNPNQSDLIEQAAEMLYGLIHARYILTNRGIAQMLEKYQQGDFGYCPRVYCENQPMLPIGLSDIPGEAMVKLYCPKCMDVYTPKSSRHHHTDGAYFGTGFPHMLFMVHPEYRPKRPANQFVPRLYGFKIHPMAYQLQLQAASNFKSPVKTIR

研究背景

機能:

Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit.

PTMs:

Phosphorylated by alpha subunit.

タンパク質ファミリー:

Belongs to the casein kinase 2 subunit beta family.

研究領域

· Cellular Processes > Cellular community - eukaryotes > Adherens junction.   (View pathway)

· Environmental Information Processing > Signal transduction > NF-kappa B signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > Wnt signaling pathway.   (View pathway)

· Genetic Information Processing > Translation > Ribosome biogenesis in eukaryotes.

· Human Diseases > Infectious diseases: Viral > Measles.

· Human Diseases > Infectious diseases: Viral > Herpes simplex infection.

· Human Diseases > Infectious diseases: Viral > Epstein-Barr virus infection.

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