Cathelicidin Recombinant Rabbit mAb - #BF4234

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製品: Cathelicidin Recombinant Rabbit mAb
カタログ: BF4234
タンパク質の説明: Rabbit monoclonal antibody to Cathelicidin
アプリケーション: WB IHC
反応性: Human
分子量: 19 kDa(Observed); 19kD(Calculated).
ユニプロット: P49913

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製品説明

ソース:
Rabbit IgG
アプリケーション:
WB 1:1000, IHC 1:500-1:2000
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human
クローナリティ:
Monoclonal [ReFirm23684]
特異性:
Cathelicidin Recombinant Rabbit mAb detects endogenous levels of Cathelicidin.
コンジュゲート:
Unconjugated.
精製:
Affinity-chromatography.
保存:
Rabbit IgG in Tris-Glycine (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

18 kDa cationic antimicrobial protein; Antibacterial peptide LL-37; Antibacterial protein FALL-39; CAMP; CAMP_HUMAN; CAP 18; CAP-18; CAP18; Cathelicidin antimicrobial peptide; Cathelin-like protein; Cathelin-related antimicrobial peptide; CATHL3; Cationic antimicrobial protein, 18-KD; CLP; Cnlp; Cramp; CRAMP, mouse, homolog of; FALL 39; FALL-39 peptide antibiotic; FALL39; hCAP 18; hCAP-18; hCAP18; HSD26; LL37; MCLP; Peptide antibiotic, PR-39, porcine, homolog of;

免疫原

免疫原:

A synthetic peptide from human Cathelicidin

Uniprot:

P49913(CAMP_HUMAN) >>Visit HPA database.

遺伝子(ID):
CAMP(820)
発現特異性:
P49913 CAMP_HUMAN:

Expressed in bone marrow and testis and neutrophils.

タンパク質の説明:
This gene encodes a member of an antimicrobial peptide family,characterized by a highly conserved N-terminal signal peptide containing a cathelin domain and a structurally variable cationic antimicrobial peptide,which is produced by extracellular proteolysis from the C-terminus. In addition to its antibacterial,antifungal,and antiviral activities,the encoded protein functions in cell chemotaxis,immune mediator induction,and inflammatory response regulation.
タンパク質配列:
MKTQRDGHSLGRWSLVLLLLGLVMPLAIIAQVLSYKEAVLRAIDGINQRSSDANLYRLLDLDPRPTMDGDPDTPKPVSFTVKETVCPRTTQQSPEDCDFKKDGLVKRCMGTVTLNQARGSFDISCDKDNKRFALLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES

研究背景

機能:

Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity.

PTMs:

The N-terminus is blocked.

細胞の位置付け:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Expressed in bone marrow and testis and neutrophils.

タンパク質ファミリー:

Belongs to the cathelicidin family.

研究領域

· Human Diseases > Infectious diseases: Bacterial > Tuberculosis.

· Organismal Systems > Immune system > NOD-like receptor signaling pathway.   (View pathway)

· Organismal Systems > Digestive system > Salivary secretion.

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