APOH Recombinant Rabbit mAb - #BF4286

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製品: APOH Recombinant Rabbit mAb
カタログ: BF4286
タンパク質の説明: Rabbit monoclonal antibody to APOH
アプリケーション: WB IF/ICC
反応性: Human, Rat
分子量: 38kDa(Observed); 38kD(Calculated).
ユニプロット: P02749

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製品説明

ソース:
Rabbit IgG
アプリケーション:
WB 1:2000-1:20000, ICC
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human, Rat
クローナリティ:
Monoclonal [ReFirm23736]
特異性:
APOH Recombinant Rabbit mAb detects endogenous levels of APOH.
コンジュゲート:
Unconjugated.
精製:
Affinity-chromatography.
保存:
Rabbit IgG in Tris-Glycine (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

Activated protein C binding protein; Activated protein C-binding protein; Anticardiolipin cofactor; APC inhibitor; Apo-H; APOH; APOH_HUMAN; apolipoprotein H (beta-2-glycoprotein I); Apolipoprotein H; B2G1; B2GP1; B2GPI; Beta 2 glycoprotein I; Beta 2 glycoprotein I precursor; Beta(2)GPI; Beta-2-glycoprotein 1; Beta-2-glycoprotein I; BG; Glycoprotein 1, beta-2; Glycoprotein I, beta-2; OTTMUSP00000003033;

免疫原

免疫原:

A synthetic peptide from human APOH

Uniprot:

P02749(APOH_HUMAN) >>Visit HPA database.

遺伝子(ID):
APOH(350)
発現特異性:
P02749 APOH_HUMAN:

Expressed by the liver and secreted in plasma.

タンパク質の説明:
Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism,coagulation,and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome,but it does not seem to be required for the reactivity of antiphospholipid autoantibodies associated with infections.
タンパク質配列:
MISPVLILFSSFLCHVAIAGRTCPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGGMRKFICPLTGLWPINTLKCTPRVCPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWTKLPECREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWSAMPSCKASCKVPVKKATVVYQGERVKIQEKFKNGMLHGDKVSFFCKNKEKKCSYTEDAQCIDGTIEVPKCFKEHSSLAFWKTDASDVKPC

研究背景

機能:

Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.

PTMs:

N- and O-glycosylated.also reports glycosylation on 'Asn-188' for their allele.

細胞の位置付け:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Expressed by the liver and secreted in plasma.

研究領域

· Organismal Systems > Digestive system > Cholesterol metabolism.

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