CREM Antibody - #DF3237
| 製品: | CREM Antibody |
| カタログ: | DF3237 |
| タンパク質の説明: | Rabbit polyclonal antibody to CREM |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Bovine, Sheep, Rabbit, Dog |
| 分子量: | 34 KD; 37kD(Calculated). |
| ユニプロット: | Q03060 |
| RRID: | AB_2835617 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF3237, RRID:AB_2835617.
折りたたみ／展開
cAMP response element modulator; cAMP responsive element modulator; cAMP-responsive element modulator; CREM; CREM-2; CREM_HUMAN; hCREM 2; hCREM-2; hCREM2; ICER; Inducible cAMP early repressor; Inducible cAMP early repressor ICER; MGC111110; MGC17881; MGC41893;
免疫原
Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes.
- Q03060 CREM_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTMETVESQHDGSITASLTESKSAHVQTQTGQNSIPALAQVSVAGSGTRRGSPAVTLVQLPSGQTIHVQGVIQTPQPWVIQSSEIHTVQVAAIAETDESAESEGVIDSHKRREILSRRPSYRKILNELSSDVPGVPKIEEERSEEEGTPPSIATMAVPTSIYQTSTGQYIAIAQGGTIQISNPGSDGVQGLQALTMTNSGAPPPGATIVQYAAQSADGTQQFFVPGSQVVVQDEETELAPSHMAAATGDMPTYQIRAPTAALPQGVVMAASPGSLHSPQQLAEEATRKRELRLMKNREAAKECRRRKKEYVKCLESRVAVLEVQNKKLIEELETLKDICSPKTDY
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q03060 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S42 | Phosphorylation | Uniprot | |
| S108 | Phosphorylation | Uniprot | |
| S116 | Phosphorylation | Uniprot | |
| S120 | Phosphorylation | Uniprot | |
| Y121 | Phosphorylation | Uniprot | |
| S129 | Phosphorylation | Uniprot | |
| T148 | Phosphorylation | Uniprot | |
| T259 | Phosphorylation | Uniprot | |
| S271 | Phosphorylation | Uniprot | |
| S274 | Phosphorylation | Uniprot | |
| S277 | Phosphorylation | Uniprot | |
| T286 | Phosphorylation | Uniprot |
研究背景
Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation.
May play a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter.
Isoform 9 is ubiquitinated by CDC34 and RAD6B in order to be degraded by the proteasome.
Stimulated by phosphorylation. Phosphorylated on Ser-116 by TSSK4 in vitro.
Nucleus.
Cytoplasm. Nucleus.
Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes.
Binds DNA as a dimer. Interacts with FHL5 (By similarity). Interacts with CDC34. May interact with TSSK4 (By similarity).
Belongs to the bZIP family.
研究領域
· Human Diseases > Infectious diseases: Viral > HTLV-I infection.
· Organismal Systems > Circulatory system > Adrenergic signaling in cardiomyocytes. (View pathway)
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