CSTF1 Antibody - #DF3241
| 製品: | CSTF1 Antibody |
| カタログ: | DF3241 |
| タンパク質の説明: | Rabbit polyclonal antibody to CSTF1 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Bovine, Horse, Sheep, Rabbit, Dog, Xenopus |
| 分子量: | 48 KD; 48kD(Calculated). |
| ユニプロット: | Q05048 |
| RRID: | AB_2835621 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF3241, RRID:AB_2835621.
折りたたみ／展開
CF 1 50 kDa subunit; CF-1 50 kDa subunit; Cleavage stimulation factor 50 kDa subunit; Cleavage stimulation factor 50kDa subunit; Cleavage stimulation factor; Cleavage stimulation factor subunit 1; Cleavage stimulation factor, 3 prime pre RNA, subunit 1, 50 kD; cleavage stimulation factor, 3' pre RNA, subunit 1, 50kD; cleavage stimulation factor, 3' pre RNA, subunit 1, 50kDa; CstF 50; CSTF 50 kDa subunit; CstF-50; CSTF1; CSTF1_HUMAN; CstFp50; OTTHUMP00000031332;
免疫原
- Q05048 CSTF1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MYRTKVGLKDRQQLYKLIISQLLYDGYISIANGLINEIKPQSVCAPSEQLLHLIKLGMENDDTAVQYAIGRSDTVAPGTGIDLEFDADVQTMSPEASEYETCYVTSHKGPCRVATYSRDGQLIATGSADASIKILDTERMLAKSAMPIEVMMNETAQQNMENHPVIRTLYDHVDEVTCLAFHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFHPSGDFILVGTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSKDGCIKLWDGVSNRCITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEISTGRTLVRYTGAGLSGRQVHRTQAVFNHTEDYVLLPDERTISLCCWDSRTAERRNLLSLGHNNIVRCIVHSPTNPGFMTCSDDFRARFWYRRSTTD
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q05048 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T63 | Phosphorylation | Uniprot | |
| Y67 | Phosphorylation | Uniprot | |
| Y195 | Phosphorylation | Uniprot | |
| K198 | Ubiquitination | Uniprot | |
| K204 | Ubiquitination | Uniprot | |
| K208 | Ubiquitination | Uniprot | |
| K287 | Ubiquitination | Uniprot | |
| K316 | Ubiquitination | Uniprot | |
| K319 | Ubiquitination | Uniprot | |
| K326 | Ubiquitination | Uniprot | |
| T364 | Phosphorylation | Uniprot | |
| Y367 | Phosphorylation | Uniprot | |
| S393 | Phosphorylation | Uniprot |
研究背景
One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA.
The N-terminus is blocked.
Nucleus.
Homodimer. The CSTF complex is composed of CSTF1 (50 kDa subunit), CSTF2 (64 kDa subunit) and CSTF3 (77 kDa subunit). Interacts (via repeats WD) directly with CSTF3. Interacts (via repeat WD6) with BARD1. Interacts with ERCC6.
N-terminus mediates homodimerization.
研究領域
· Genetic Information Processing > Translation > mRNA surveillance pathway.
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