MMP15 Antibody - #AF0213
| 製品: | MMP15 Antibody |
| カタログ: | AF0213 |
| タンパク質の説明: | Rabbit polyclonal antibody to MMP15 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse |
| 予測: | Bovine, Horse, Sheep, Dog, Chicken |
| 分子量: | 80kDa, 70 kDa; 76kD(Calculated). |
| ユニプロット: | P51511 |
| RRID: | AB_2833283 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF0213, RRID:AB_2833283.
折りたたみ／展開
AI503551; Matrix metallopeptidase 15 membrane inserted; Matrix metalloproteinase 15; Matrix metalloproteinase-15; Membrane type 2 matrix metalloproteinase; Membrane type matrix metalloproteinase 2; Membrane-type matrix metalloproteinase 2; Membrane-type-2 matrix metalloproteinase; MMP 15; MMP-15; MMP15; MMP15_HUMAN; MT MMP 2; MT-MMP 2; MT2 MMP; MT2-MMP; MT2MMP; MTMMP 2; MTMMP2; SMCP 2; SMCP-2; SMCP2;
免疫原
Appeared to be synthesized preferentially in liver, placenta, testis, colon and intestine. Substantial amounts are also detected in pancreas, kidney, lung, heart and skeletal muscle.
- P51511 MMP15_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGSDPSAPGRPGWTGSLLGDREEAARPRLLPLLLVLLGCLGLGVAAEDAEVHAENWLRLYGYLPQPSRHMSTMRSAQILASALAEMQRFYGIPVTGVLDEETKEWMKRPRCGVPDQFGVRVKANLRRRRKRYALTGRKWNNHHLTFSIQNYTEKLGWYHSMEAVRRAFRVWEQATPLVFQEVPYEDIRLRRQKEADIMVLFASGFHGDSSPFDGTGGFLAHAYFPGPGLGGDTHFDADEPWTFSSTDLHGNNLFLVAVHELGHALGLEHSSNPNAIMAPFYQWKDVDNFKLPEDDLRGIQQLYGTPDGQPQPTQPLPTVTPRRPGRPDHRPPRPPQPPPPGGKPERPPKPGPPVQPRATERPDQYGPNICDGDFDTVAMLRGEMFVFKGRWFWRVRHNRVLDNYPMPIGHFWRGLPGDISAAYERQDGRFVFFKGDRYWLFREANLEPGYPQPLTSYGLGIPYDRIDTAIWWEPTGHTFFFQEDRYWRFNEETQRGDPGYPKPISVWQGIPASPKGAFLSNDAAYTYFYKGTKYWKFDNERLRMEPGYPKSILRDFMGCQEHVEPGPRWPDVARPPFNPHGGAEPGADSAEGDVGDGDGDFGAGVNKDGGSRVVVQMEEVARTVNVVMVLVPLLLLLCVLGLTYALVQMQRKGAPRVLLYCKRSLQEWV
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P51511 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S67 | Phosphorylation | Uniprot | |
| T305 | O-Glycosylation | Uniprot | |
| T313 | O-Glycosylation | Uniprot | |
| T318 | O-Glycosylation | Uniprot | |
| T320 | O-Glycosylation | Uniprot | |
| K388 | Ubiquitination | Uniprot | |
| S551 | Phosphorylation | Uniprot | |
| S589 | Phosphorylation | Uniprot | |
| Y660 | Phosphorylation | Uniprot | |
| K662 | Ubiquitination | Uniprot |
研究背景
Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A.
The precursor is cleaved by a furin endopeptidase.
Membrane>Single-pass type I membrane protein>Extracellular side.
Appeared to be synthesized preferentially in liver, placenta, testis, colon and intestine. Substantial amounts are also detected in pancreas, kidney, lung, heart and skeletal muscle.
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Belongs to the peptidase M10A family.
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